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DNA looping mediates nucleosome transfer

Author

Listed:
  • Lucy D. Brennan

    (Cornell University)

  • Robert A. Forties

    (Cornell University
    Howard Hughes Medical Institute, Cornell University
    Present address: Advion Inc., 30 Brown Road, Ithaca, New York 14850, USA)

  • Smita S. Patel

    (Rutgers-Robert Wood Johnson Medical School)

  • Michelle D. Wang

    (Cornell University
    Howard Hughes Medical Institute, Cornell University)

Abstract

Proper cell function requires preservation of the spatial organization of chromatin modifications. Maintenance of this epigenetic landscape necessitates the transfer of parental nucleosomes to newly replicated DNA, a process that is stringently regulated and intrinsically linked to replication fork dynamics. This creates a formidable setting from which to isolate the central mechanism of transfer. Here we utilized a minimal experimental system to track the fate of a single nucleosome following its displacement, and examined whether DNA mechanics itself, in the absence of any chaperones or assembly factors, may serve as a platform for the transfer process. We found that the nucleosome is passively transferred to available dsDNA as predicted by a simple physical model of DNA loop formation. These results demonstrate a fundamental role for DNA mechanics in mediating nucleosome transfer and preserving epigenetic integrity during replication.

Suggested Citation

  • Lucy D. Brennan & Robert A. Forties & Smita S. Patel & Michelle D. Wang, 2016. "DNA looping mediates nucleosome transfer," Nature Communications, Nature, vol. 7(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13337
    DOI: 10.1038/ncomms13337
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    Cited by:

    1. Jaeyoon Lee & Meiling Wu & James T. Inman & Gundeep Singh & Seong ha Park & Joyce H. Lee & Robert M. Fulbright & Yifeng Hong & Joshua Jeong & James M. Berger & Michelle D. Wang, 2023. "Chromatinization modulates topoisomerase II processivity," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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