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Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction

Author

Listed:
  • Shuting Zhao

    (The Ohio State University
    Davis Heart and Lung Research Institute, The Ohio State University)

  • Zhaobin Xu

    (Davis Heart and Lung Research Institute, The Ohio State University
    The Ohio State University)

  • Hai Wang

    (The Ohio State University
    Davis Heart and Lung Research Institute, The Ohio State University)

  • Benjamin E. Reese

    (The Ohio State University
    Davis Heart and Lung Research Institute, The Ohio State University)

  • Liubov V. Gushchina

    (Davis Heart and Lung Research Institute, The Ohio State University
    The Ohio State University)

  • Meng Jiang

    (Davis Heart and Lung Research Institute, The Ohio State University
    The Ohio State University)

  • Pranay Agarwal

    (The Ohio State University
    Davis Heart and Lung Research Institute, The Ohio State University)

  • Jiangsheng Xu

    (The Ohio State University
    Davis Heart and Lung Research Institute, The Ohio State University)

  • Mingjun Zhang

    (The Ohio State University
    Davis Heart and Lung Research Institute, The Ohio State University)

  • Rulong Shen

    (The Ohio State University)

  • Zhenguo Liu

    (Davis Heart and Lung Research Institute, The Ohio State University
    The Ohio State University)

  • Noah Weisleder

    (Davis Heart and Lung Research Institute, The Ohio State University
    The Ohio State University)

  • Xiaoming He

    (The Ohio State University
    Davis Heart and Lung Research Institute, The Ohio State University
    Comprehensive Cancer Center, The Ohio State University)

Abstract

It is difficult to achieve minimally invasive injectable cell delivery while maintaining high cell retention and animal survival for in vivo stem cell therapy of myocardial infarction. Here we show that pluripotent stem cell aggregates pre-differentiated into the early cardiac lineage and encapsulated in a biocompatible and biodegradable micromatrix, are suitable for injectable delivery. This method significantly improves the survival of the injected cells by more than six-fold compared with the conventional practice of injecting single cells, and effectively prevents teratoma formation. Moreover, this method significantly enhances cardiac function and survival of animals after myocardial infarction, as a result of a localized immunosuppression effect of the micromatrix and the in situ cardiac regeneration by the injected cells.

Suggested Citation

  • Shuting Zhao & Zhaobin Xu & Hai Wang & Benjamin E. Reese & Liubov V. Gushchina & Meng Jiang & Pranay Agarwal & Jiangsheng Xu & Mingjun Zhang & Rulong Shen & Zhenguo Liu & Noah Weisleder & Xiaoming He, 2016. "Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction," Nature Communications, Nature, vol. 7(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13306
    DOI: 10.1038/ncomms13306
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