Author
Listed:
- Elisa Romanelli
(Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians University Munich)
- Doron Merkler
(University of Geneva
Geneva University Hospital)
- Aleksandra Mezydlo
(Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians University Munich)
- Marie-Theres Weil
(Max-Planck Institute of Experimental Medicine
Georg-August University Göttingen)
- Martin S. Weber
(Georg-August University Göttingen
Institute of Neuropathology, Georg-August University Göttingen)
- Ivana Nikić
(Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians University Munich)
- Stephanie Potz
(Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians University Munich)
- Edgar Meinl
(Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians University Munich)
- Florian E. H. Matznick
(Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians University Munich)
- Mario Kreutzfeldt
(University of Geneva)
- Alexander Ghanem
(Max von Pettenkofer-Institute and Gene Center, Ludwig-Maximilians University Munich)
- Karl-Klaus Conzelmann
(Max von Pettenkofer-Institute and Gene Center, Ludwig-Maximilians University Munich)
- Imke Metz
(Institute of Neuropathology, Georg-August University Göttingen)
- Wolfgang Brück
(Institute of Neuropathology, Georg-August University Göttingen)
- Matthew Routh
(Ball State University)
- Mikael Simons
(Max-Planck Institute of Experimental Medicine
Georg-August University Göttingen
German Center for Neurodegenerative Diseases (DZNE)
Institute of Neuronal Cell Biology, Technical University Munich)
- Derron Bishop
(Indiana University School of Medicine)
- Thomas Misgeld
(German Center for Neurodegenerative Diseases (DZNE)
Institute of Neuronal Cell Biology, Technical University Munich
Munich Cluster of Systems Neurology (SyNergy)
Center of Integrated Protein Sciences (CIPS))
- Martin Kerschensteiner
(Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians University Munich
Munich Cluster of Systems Neurology (SyNergy))
Abstract
Oligodendrocyte damage is a central event in the pathogenesis of the common neuroinflammatory condition, multiple sclerosis (MS). Where and how oligodendrocyte damage is initiated in MS is not completely understood. Here, we use a combination of light and electron microscopy techniques to provide a dynamic and highly resolved view of oligodendrocyte damage in neuroinflammatory lesions. We show that both in MS and in its animal model structural damage is initiated at the myelin sheaths and only later spreads to the oligodendrocyte cell body. Early myelin damage itself is characterized by the formation of local myelin out-foldings—‘myelinosomes’—, which are surrounded by phagocyte processes and promoted in their formation by anti-myelin antibodies and complement. The presence of myelinosomes in actively demyelinating MS lesions suggests that oligodendrocyte damage follows a similar pattern in the human disease, where targeting demyelination by therapeutic interventions remains a major open challenge.
Suggested Citation
Elisa Romanelli & Doron Merkler & Aleksandra Mezydlo & Marie-Theres Weil & Martin S. Weber & Ivana Nikić & Stephanie Potz & Edgar Meinl & Florian E. H. Matznick & Mario Kreutzfeldt & Alexander Ghanem , 2016.
"Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model,"
Nature Communications, Nature, vol. 7(1), pages 1-10, December.
Handle:
RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13275
DOI: 10.1038/ncomms13275
Download full text from publisher
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13275. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
We have no bibliographic references for this item. You can help adding them by using this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through
the various RePEc services.