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Genomic heterogeneity of multiple synchronous lung cancer

Author

Listed:
  • Yu Liu

    (State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences)

  • Jianjun Zhang

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • Lin Li

    (State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
    Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences)

  • Guangliang Yin

    (Beijing Genomics Institute)

  • Jianhua Zhang

    (Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center)

  • Shan Zheng

    (Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences)

  • Hannah Cheung

    (The University of Texas MD Anderson Cancer Center)

  • Ning Wu

    (Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences)

  • Ning Lu

    (Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences)

  • Xizeng Mao

    (Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center)

  • Longhai Yang

    (Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences)

  • Jiexin Zhang

    (The University of Texas MD Anderson Cancer Center)

  • Li Zhang

    (Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences)

  • Sahil Seth

    (Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center)

  • Huang Chen

    (State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences)

  • Xingzhi Song

    (Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center)

  • Kan Liu

    (Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences)

  • Yongqiang Xie

    (Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences)

  • Lina Zhou

    (Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences)

  • Chuanduo Zhao

    (Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences)

  • Naijun Han

    (State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences)

  • Wenting Chen

    (State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences)

  • Susu Zhang

    (State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences)

  • Longyun Chen

    (Beijing Genomics Institute)

  • Wenjun Cai

    (Beijing Genomics Institute)

  • Lin Li

    (Beijing Genomics Institute)

  • Miaozhong Shen

    (Beijing Genomics Institute)

  • Ningzhi Xu

    (State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences)

  • Shujun Cheng

    (State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences)

  • Huanming Yang

    (Beijing Genomics Institute)

  • J. Jack Lee

    (The University of Texas MD Anderson Cancer Center)

  • Arlene Correa

    (The University of Texas MD Anderson Cancer Center)

  • Junya Fujimoto

    (The University of Texas MD Anderson Cancer Center)

  • Carmen Behrens

    (The University of Texas MD Anderson Cancer Center)

  • Chi-Wan Chow

    (The University of Texas MD Anderson Cancer Center)

  • William N. William

    (The University of Texas MD Anderson Cancer Center)

  • John V. Heymach

    (The University of Texas MD Anderson Cancer Center)

  • Waun Ki Hong

    (The University of Texas MD Anderson Cancer Center)

  • Stephen Swisher

    (The University of Texas MD Anderson Cancer Center)

  • Ignacio I. Wistuba

    (The University of Texas MD Anderson Cancer Center)

  • Jun Wang

    (Beijing Genomics Institute
    University of Copenhagen)

  • Dongmei Lin

    (Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences)

  • Xiangyang Liu

    (Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences)

  • P. Andrew Futreal

    (The University of Texas MD Anderson Cancer Center
    Honorary Faculty, Wellcome Trust Sanger Institute)

  • Yanning Gao

    (State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences)

Abstract

Multiple synchronous lung cancers (MSLCs) present a clinical dilemma as to whether individual tumours represent intrapulmonary metastases or independent tumours. In this study we analyse genomic profiles of 15 lung adenocarcinomas and one regional lymph node metastasis from 6 patients with MSLC. All 15 lung tumours demonstrate distinct genomic profiles, suggesting all are independent primary tumours, which are consistent with comprehensive histopathological assessment in 5 of the 6 patients. Lung tumours of the same individuals are no more similar to each other than are lung adenocarcinomas of different patients from TCGA cohort matched for tumour size and smoking status. Several known cancer-associated genes have different mutations in different tumours from the same patients. These findings suggest that in the context of identical constitutional genetic background and environmental exposure, different lung cancers in the same individual may have distinct genomic profiles and can be driven by distinct molecular events.

Suggested Citation

  • Yu Liu & Jianjun Zhang & Lin Li & Guangliang Yin & Jianhua Zhang & Shan Zheng & Hannah Cheung & Ning Wu & Ning Lu & Xizeng Mao & Longhai Yang & Jiexin Zhang & Li Zhang & Sahil Seth & Huang Chen & Xing, 2016. "Genomic heterogeneity of multiple synchronous lung cancer," Nature Communications, Nature, vol. 7(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13200
    DOI: 10.1038/ncomms13200
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    Cited by:

    1. Ming Tang & Hussein A. Abbas & Marcelo V. Negrao & Maheshwari Ramineni & Xin Hu & Shawna Marie Hubert & Junya Fujimoto & Alexandre Reuben & Susan Varghese & Jianhua Zhang & Jun Li & Chi-Wan Chow & Xiz, 2021. "The histologic phenotype of lung cancers is associated with transcriptomic features rather than genomic characteristics," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    2. Yue Zhao & Jian Gao & Jun Wang & Fanfan Fan & Chao Cheng & Danwen Qian & Ran Guo & Yang Zhang & Ting Ye & Marcellus Augustine & Yicong Lin & Jun Shang & Hang Li & Yunjian Pan & Qingyuan Huang & Haiqin, 2024. "Genomic and immune heterogeneity of multiple synchronous lung adenocarcinoma at different developmental stages," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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