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Stereotypic wheel running decreases cortical activity in mice

Author

Listed:
  • Simon P. Fisher

    (Anatomy and Genetics, University of Oxford
    Present address: Medical Research Council, Polaris House, North Star Avenue, Swindon SN2 1FL, UK)

  • Nanyi Cui

    (Anatomy and Genetics, University of Oxford)

  • Laura E. McKillop

    (Anatomy and Genetics, University of Oxford)

  • Jessica Gemignani

    (European Space Agency, Advanced Concepts Team)

  • David M. Bannerman

    (University of Oxford)

  • Peter L. Oliver

    (Anatomy and Genetics, University of Oxford)

  • Stuart N. Peirson

    (Sleep and Circadian Neuroscience Institute, University of Oxford)

  • Vladyslav V. Vyazovskiy

    (Anatomy and Genetics, University of Oxford)

Abstract

Prolonged wakefulness is thought to gradually increase ‘sleep need’ and influence subsequent sleep duration and intensity, but the role of specific waking behaviours remains unclear. Here we report the effect of voluntary wheel running during wakefulness on neuronal activity in the motor and somatosensory cortex in mice. We find that stereotypic wheel running is associated with a substantial reduction in firing rates among a large subpopulation of cortical neurons, especially at high speeds. Wheel running also has longer-term effects on spiking activity across periods of wakefulness. Specifically, cortical firing rates are significantly higher towards the end of a spontaneous prolonged waking period. However, this increase is abolished when wakefulness is dominated by running wheel activity. These findings indicate that wake-related changes in firing rates are determined not only by wake duration, but also by specific waking behaviours.

Suggested Citation

  • Simon P. Fisher & Nanyi Cui & Laura E. McKillop & Jessica Gemignani & David M. Bannerman & Peter L. Oliver & Stuart N. Peirson & Vladyslav V. Vyazovskiy, 2016. "Stereotypic wheel running decreases cortical activity in mice," Nature Communications, Nature, vol. 7(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13138
    DOI: 10.1038/ncomms13138
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    Cited by:

    1. Amelia J. Christensen & Jonathan W. Pillow, 2022. "Reduced neural activity but improved coding in rodent higher-order visual cortex during locomotion," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    2. HaoRan Chang & Ingrid M. Esteves & Adam R. Neumann & Majid H. Mohajerani & Bruce L. McNaughton, 2023. "Cortical reactivation of spatial and non-spatial features coordinates with hippocampus to form a memory dialogue," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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