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Distinct gene expression patterns correlate with developmental and functional traits of iNKT subsets

Author

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  • Hristo Georgiev

    (Institute of Immunology, Hannover Medical School)

  • Inga Ravens

    (Institute of Immunology, Hannover Medical School)

  • Charaf Benarafa

    (Theodor Kocher Institute, University of Bern)

  • Reinhold Förster

    (Institute of Immunology, Hannover Medical School)

  • Günter Bernhardt

    (Institute of Immunology, Hannover Medical School)

Abstract

Invariant natural killer T (iNKT) cells comprise a subpopulation of innate lymphocytes developing in thymus. A new model proposes subdividing murine iNKT cells into iNKT1, 2 and 17 cells. Here, we use transcriptome analyses of iNKT1, 2 and 17 subsets isolated from BALB/c and C57BL/6 thymi to identify candidate genes that may affect iNKT cell development, migration or function. We show that Fcɛr1γ is involved in generation of iNKT1 cells and that SerpinB1 modulates frequency of iNKT17 cells. Moreover, a considerable proportion of iNKT17 cells express IL-4 and IL-17 simultaneously. The results presented not only validate the usefulness of the iNKT1/2/17-concept but also provide new insights into iNKT cell biology.

Suggested Citation

  • Hristo Georgiev & Inga Ravens & Charaf Benarafa & Reinhold Förster & Günter Bernhardt, 2016. "Distinct gene expression patterns correlate with developmental and functional traits of iNKT subsets," Nature Communications, Nature, vol. 7(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13116
    DOI: 10.1038/ncomms13116
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    Cited by:

    1. Ludivine Amable & Luis Antonio Ferreira Martins & Remi Pierre & Marcio Cruseiro & Ghita Chabab & Arnauld Sergé & Camille Kergaravat & Marc Delord & Christophe Viret & Jean Jaubert & Chaohong Liu & Sao, 2023. "Intrinsic factors and CD1d1 but not CD1d2 expression levels control invariant natural killer T cell subset differentiation," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Moriya Tsuji & Manoj S. Nair & Kazuya Masuda & Candace Castagna & Zhenlu Chong & Tamarand L. Darling & Kuljeet Seehra & Youngmin Hwang & Ágata Lopes Ribeiro & Geovane Marques Ferreira & Laura Corredor, 2023. "An immunostimulatory glycolipid that blocks SARS-CoV-2, RSV, and influenza infections in vivo," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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