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Spatiotemporal control of cell–cell reversible interactions using molecular engineering

Author

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  • Peng Shi

    (Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Enguo Ju

    (Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Zhengqing Yan

    (Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Nan Gao

    (Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences)

  • Jiasi Wang

    (Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Jianwen Hou

    (University of Chinese Academy of Sciences)

  • Yan Zhang

    (College of life science, Jilin University)

  • Jinsong Ren

    (Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences)

  • Xiaogang Qu

    (Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences)

Abstract

Manipulation of cell–cell interactions has potential applications in basic research and cell-based therapy. Herein, using a combination of metabolic glycan labelling and bio-orthogonal click reaction, we engineer cell membranes with β-cyclodextrin and subsequently manipulate cell behaviours via photo-responsive host-guest recognition. With this methodology, we demonstrate reversible manipulation of cell assembly and disassembly. The method enables light-controllable reversible assembly of cell–cell adhesion, in contrast with previously reported irreversible effects, in which altered structure could not be reused. We also illustrate the utility of the method by designing a cell-based therapy. Peripheral blood mononuclear cells modified with aptamer are effectively redirected towards target cells, resulting in enhanced cell apoptosis. Our approach allows precise control of reversible cell–cell interactions and we expect that it will promote further developments of cell-based therapy.

Suggested Citation

  • Peng Shi & Enguo Ju & Zhengqing Yan & Nan Gao & Jiasi Wang & Jianwen Hou & Yan Zhang & Jinsong Ren & Xiaogang Qu, 2016. "Spatiotemporal control of cell–cell reversible interactions using molecular engineering," Nature Communications, Nature, vol. 7(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13088
    DOI: 10.1038/ncomms13088
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