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Divergent effects of central melanocortin signalling on fat and sucrose preference in humans

Author

Listed:
  • Agatha A. van der Klaauw

    (Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science)

  • Julia M. Keogh

    (Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science)

  • Elana Henning

    (Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science)

  • Cheryl Stephenson

    (Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science)

  • Sarah Kelway

    (Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science)

  • Victoria M. Trowse

    (Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science)

  • Naresh Subramanian

    (Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science
    University of Cambridge and the Cambridgeshire and Peterborough NHS Foundation Trust Cambridge)

  • Stephen O’Rahilly

    (Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science)

  • Paul C. Fletcher

    (Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science
    University of Cambridge and the Cambridgeshire and Peterborough NHS Foundation Trust Cambridge)

  • I. Sadaf Farooqi

    (Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science)

Abstract

Melanocortin-4-receptor (MC4R)-expressing neurons modulate food intake and preference in rodents but their role in human food preference is unknown. Here we show that compared with lean and weight-matched controls, MC4R deficient individuals exhibited a markedly increased preference for high fat, but a significantly reduced preference for high sucrose food. These effects mirror those in Mc4r null rodents and provide evidence for a central molecular circuit influencing human macronutrient preference.

Suggested Citation

  • Agatha A. van der Klaauw & Julia M. Keogh & Elana Henning & Cheryl Stephenson & Sarah Kelway & Victoria M. Trowse & Naresh Subramanian & Stephen O’Rahilly & Paul C. Fletcher & I. Sadaf Farooqi, 2016. "Divergent effects of central melanocortin signalling on fat and sucrose preference in humans," Nature Communications, Nature, vol. 7(1), pages 1-5, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13055
    DOI: 10.1038/ncomms13055
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