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Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig

Author

Listed:
  • Jianzhao Liu

    (Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago)

  • Yuanxiang Zhu

    (State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences)

  • Guan-Zheng Luo

    (Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago)

  • Xinxia Wang

    (Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
    Key Laboratory of Animal Nutrition and Feed Sciences, Ministry of Agriculture, College of Animal Sciences, Zhejiang University)

  • Yanan Yue

    (Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago)

  • Xiaona Wang

    (State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences)

  • Xin Zong

    (Key Laboratory of Animal Nutrition and Feed Sciences, Ministry of Agriculture, College of Animal Sciences, Zhejiang University)

  • Kai Chen

    (Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago)

  • Hang Yin

    (Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago)

  • Ye Fu

    (Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago)

  • Dali Han

    (Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago)

  • Yizhen Wang

    (Key Laboratory of Animal Nutrition and Feed Sciences, Ministry of Agriculture, College of Animal Sciences, Zhejiang University)

  • Dahua Chen

    (State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences)

  • Chuan He

    (Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago)

Abstract

DNA N6-methyldeoxyadenosine (6mA) is a well-known prokaryotic DNA modification that has been shown to exist and play epigenetic roles in eukaryotic DNA. Here we report that 6mA accumulates up to ∼0.1–0.2% of total deoxyadenosine during early embryogenesis of vertebrates, but diminishes to the background level with the progression of the embryo development. During this process a large fraction of 6mAs locate in repetitive regions of the genome.

Suggested Citation

  • Jianzhao Liu & Yuanxiang Zhu & Guan-Zheng Luo & Xinxia Wang & Yanan Yue & Xiaona Wang & Xin Zong & Kai Chen & Hang Yin & Ye Fu & Dali Han & Yizhen Wang & Dahua Chen & Chuan He, 2016. "Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig," Nature Communications, Nature, vol. 7(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13052
    DOI: 10.1038/ncomms13052
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