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Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy

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  • Jundong Shao

    (Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
    SZU-NUS Collaborative Innovation Center for Optoelectronic Science and Technology, and Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University)

  • Hanhan Xie

    (Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences)

  • Hao Huang

    (Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences)

  • Zhibin Li

    (Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences)

  • Zhengbo Sun

    (SZU-NUS Collaborative Innovation Center for Optoelectronic Science and Technology, and Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University)

  • Yanhua Xu

    (SZU-NUS Collaborative Innovation Center for Optoelectronic Science and Technology, and Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University)

  • Quanlan Xiao

    (SZU-NUS Collaborative Innovation Center for Optoelectronic Science and Technology, and Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University)

  • Xue-Feng Yu

    (Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences)

  • Yuetao Zhao

    (Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences)

  • Han Zhang

    (SZU-NUS Collaborative Innovation Center for Optoelectronic Science and Technology, and Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University)

  • Huaiyu Wang

    (Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences)

  • Paul K. Chu

    (City University of Hong Kong)

Abstract

Photothermal therapy (PTT) offers many advantages such as high efficiency and minimal invasiveness, but clinical adoption of PTT nanoagents have been stifled by unresolved concerns such as the biodegradability as well as long-term toxicity. Herein, poly (lactic-co-glycolic acid) (PLGA) loaded with black phosphorus quantum dots (BPQDs) is processed by an emulsion method to produce biodegradable BPQDs/PLGA nanospheres. The hydrophobic PLGA not only isolates the interior BPQDs from oxygen and water to enhance the photothermal stability, but also control the degradation rate of the BPQDs. The in vitro and in vivo experiments demonstrate that the BPQDs/PLGA nanospheres have inappreciable toxicity and good biocompatibility, and possess excellent PTT efficiency and tumour targeting ability as evidenced by highly efficient tumour ablation under near infrared (NIR) laser illumination. These BP-based nanospheres combine biodegradability and biocompatibility with high PTT efficiency, thus promising high clinical potential.

Suggested Citation

  • Jundong Shao & Hanhan Xie & Hao Huang & Zhibin Li & Zhengbo Sun & Yanhua Xu & Quanlan Xiao & Xue-Feng Yu & Yuetao Zhao & Han Zhang & Huaiyu Wang & Paul K. Chu, 2016. "Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy," Nature Communications, Nature, vol. 7(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12967
    DOI: 10.1038/ncomms12967
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    Cited by:

    1. Siqi Yu & Yu Du & Xianghong Niu & Guangming Li & Da Zhu & Qian Yu & Guizheng Zou & Huangxian Ju, 2022. "Arginine-modified black phosphorus quantum dots with dual excited states for enhanced electrochemiluminescence in bioanalysis," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    2. Li, Zhijing & Lei, Hui & Kan, Ankang & Xie, Huaqing & Yu, Wei, 2021. "Photothermal applications based on graphene and its derivatives: A state-of-the-art review," Energy, Elsevier, vol. 216(C).

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