IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v7y2016i1d10.1038_ncomms12943.html
   My bibliography  Save this article

Bmi1 marks distinct castration-resistant luminal progenitor cells competent for prostate regeneration and tumour initiation

Author

Listed:
  • Young A. Yoo

    (Northwestern University Feinberg School of Medicine)

  • Meejeon Roh

    (Northwestern University Feinberg School of Medicine
    The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine)

  • Anum F. Naseem

    (Northwestern University Feinberg School of Medicine)

  • Barbara Lysy

    (Northwestern University Feinberg School of Medicine)

  • Mohamed M. Desouki

    (Microbiology and Immunology, Vanderbilt University School of Medicine)

  • Kenji Unno

    (Northwestern University Feinberg School of Medicine)

  • Sarki A. Abdulkadir

    (Northwestern University Feinberg School of Medicine
    The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine
    Northwestern University Feinberg School of Medicine)

Abstract

Identification of defined cell populations with stem/progenitor properties is key for understanding prostate development and tumorigenesis. Here we show that the polycomb repressor protein Bmi1 marks a population of castration-resistant luminal epithelial cells enriched in the mouse proximal prostate. We employ lineage tracing to show that these castration-resistant Bmi1-expressing cells (or CARBs) are capable of tissue regeneration and self-renewal. Notably, CARBs are distinct from the previously described luminal castration-resistant Nkx3.1-expressing cells (CARNs). CARBs can serve as a prostate cancer cell-of-origin upon Pten deletion, yielding luminal prostate tumours. Clonal analysis using the R26R-confetti allele indicates preferential tumour initiation from CARBs localized to the proximal prostate. These studies identify Bmi1 as a marker for a distinct population of castration-resistant luminal epithelial cells enriched in the proximal prostate that can serve as a cell of origin for prostate cancer.

Suggested Citation

  • Young A. Yoo & Meejeon Roh & Anum F. Naseem & Barbara Lysy & Mohamed M. Desouki & Kenji Unno & Sarki A. Abdulkadir, 2016. "Bmi1 marks distinct castration-resistant luminal progenitor cells competent for prostate regeneration and tumour initiation," Nature Communications, Nature, vol. 7(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12943
    DOI: 10.1038/ncomms12943
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms12943
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms12943?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12943. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.