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A polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques

Author

Listed:
  • Sujin Lee

    (Emory University
    Children’s Healthcare of Atlanta)

  • Minh Trang Nguyen

    (Emory University
    Children’s Healthcare of Atlanta)

  • Michael G. Currier

    (Emory University
    Children’s Healthcare of Atlanta)

  • Joe B. Jenkins

    (Yerkes National Primate Research Center, Emory University)

  • Elizabeth A. Strobert

    (Yerkes National Primate Research Center, Emory University)

  • Adriana E. Kajon

    (Infectious Disease Program, Lovelace Respiratory Research Institute)

  • Ranjna Madan-Lala

    (Georgia Institute of Technology)

  • Yury A. Bochkov

    (University of Wisconsin-Madison)

  • James E. Gern

    (University of Wisconsin-Madison
    University of Wisconsin-Madison)

  • Krishnendu Roy

    (Georgia Institute of Technology)

  • Xiaoyan Lu

    (Centers for Disease Control and Prevention)

  • Dean D. Erdman

    (Centers for Disease Control and Prevention)

  • Paul Spearman

    (Emory University
    Children’s Healthcare of Atlanta)

  • Martin L. Moore

    (Emory University
    Children’s Healthcare of Atlanta)

Abstract

As the predominant aetiological agent of the common cold, human rhinovirus (HRV) is the leading cause of human infectious disease. Early studies showed that a monovalent formalin-inactivated HRV vaccine can be protective, and virus-neutralizing antibodies (nAb) correlated with protection. However, co-circulation of many HRV types discouraged further vaccine efforts. Here, we test the hypothesis that increasing virus input titres in polyvalent inactivated HRV vaccine may result in broad nAb responses. We show that serum nAb against many rhinovirus types can be induced by polyvalent, inactivated HRVs plus alhydrogel (alum) adjuvant. Using formulations up to 25-valent in mice and 50-valent in rhesus macaques, HRV vaccine immunogenicity was related to sufficient quantity of input antigens, and valency was not a major factor for potency or breadth of the response. Thus, we have generated a vaccine capable of inducing nAb responses to numerous and diverse HRV types.

Suggested Citation

  • Sujin Lee & Minh Trang Nguyen & Michael G. Currier & Joe B. Jenkins & Elizabeth A. Strobert & Adriana E. Kajon & Ranjna Madan-Lala & Yury A. Bochkov & James E. Gern & Krishnendu Roy & Xiaoyan Lu & Dea, 2016. "A polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques," Nature Communications, Nature, vol. 7(1), pages 1-7, November.
  • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12838
    DOI: 10.1038/ncomms12838
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