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Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene

Author

Listed:
  • Gijs van Ingen

    (Head and Neck Surgery, Erasmus MC, University Medical Center Rotterdam
    The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam)

  • Jin Li

    (Center for Applied Genomics, Children’s Hospital of Philadelphia)

  • André Goedegebure

    (Head and Neck Surgery, Erasmus MC, University Medical Center Rotterdam)

  • Rahul Pandey

    (Center for Applied Genomics, Children’s Hospital of Philadelphia)

  • Yun Rose Li

    (Center for Applied Genomics, Children’s Hospital of Philadelphia)

  • Michael E. March

    (Center for Applied Genomics, Children’s Hospital of Philadelphia)

  • Vincent W. V. Jaddoe

    (The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
    Erasmus MC, University Medical Center Rotterdam
    Erasmus MC, University Medical Center Rotterdam)

  • Marina Bakay

    (Center for Applied Genomics, Children’s Hospital of Philadelphia)

  • Frank D. Mentch

    (Center for Applied Genomics, Children’s Hospital of Philadelphia)

  • Kelly Thomas

    (Center for Applied Genomics, Children’s Hospital of Philadelphia)

  • Zhi Wei

    (New Jersey Institute of Technology)

  • Xiao Chang

    (Center for Applied Genomics, Children’s Hospital of Philadelphia)

  • Heather S. Hain

    (Center for Applied Genomics, Children’s Hospital of Philadelphia)

  • André G. Uitterlinden

    (Erasmus MC, University Medical Center Rotterdam
    Erasmus MC, University Medical Center Rotterdam)

  • Henriette A. Moll

    (Erasmus MC, University Medical Center Rotterdam)

  • Cornelia M. van Duijn

    (Erasmus MC, University Medical Center Rotterdam)

  • Fernando Rivadeneira

    (Erasmus MC, University Medical Center Rotterdam
    Erasmus MC, University Medical Center Rotterdam)

  • Hein Raat

    (Erasmus MC, University Medical Center Rotterdam)

  • Robert J. Baatenburg de Jong

    (Head and Neck Surgery, Erasmus MC, University Medical Center Rotterdam)

  • Patrick M. Sleiman

    (Center for Applied Genomics, Children’s Hospital of Philadelphia)

  • Marc P. van der Schroeff

    (Head and Neck Surgery, Erasmus MC, University Medical Center Rotterdam)

  • Hakon Hakonarson

    (Center for Applied Genomics, Children’s Hospital of Philadelphia
    Children's Hospital of Philadelphia
    The Perelman School of Medicine, University of Pennsylvania)

Abstract

Acute otitis media (AOM) is among the most common pediatric diseases, and the most frequent reason for antibiotic treatment in children. Risk of AOM is dependent on environmental and host factors, as well as a significant genetic component. We identify genome-wide significance at a locus on 6q25.3 (rs2932989, Pmeta=2.15 × 10−09), and show that the associated variants are correlated with the methylation status of the FNDC1 gene (cg05678571, P=1.43 × 10−06), and further show it is an eQTL for FNDC1 (P=9.3 × 10−05). The mouse homologue, Fndc1, is expressed in middle ear tissue and its expression is upregulated upon lipopolysaccharide treatment. In this first GWAS of AOM and the largest OM genetic study to date, we identify the first genome-wide significant locus associated with AOM.

Suggested Citation

  • Gijs van Ingen & Jin Li & André Goedegebure & Rahul Pandey & Yun Rose Li & Michael E. March & Vincent W. V. Jaddoe & Marina Bakay & Frank D. Mentch & Kelly Thomas & Zhi Wei & Xiao Chang & Heather S. H, 2016. "Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene," Nature Communications, Nature, vol. 7(1), pages 1-7, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12792
    DOI: 10.1038/ncomms12792
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