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Principal cell activity induces spine relocation of adult-born interneurons in the olfactory bulb

Author

Listed:
  • Vincent Breton-Provencher

    (Cellular Neurobiology Unit,Institut Universitaire en santé mentale de Québec)

  • Karen Bakhshetyan

    (Cellular Neurobiology Unit,Institut Universitaire en santé mentale de Québec)

  • Delphine Hardy

    (Cellular Neurobiology Unit,Institut Universitaire en santé mentale de Québec)

  • Rodrigo Roberto Bammann

    (Cellular Neurobiology Unit,Institut Universitaire en santé mentale de Québec)

  • Francesco Cavarretta

    (University of Milan
    Yale University School of Medicine)

  • Marina Snapyan

    (Cellular Neurobiology Unit,Institut Universitaire en santé mentale de Québec)

  • Daniel Côté

    (Cellular Neurobiology Unit,Institut Universitaire en santé mentale de Québec
    Centre d’optique, photonique et laser (COPL), Université Laval)

  • Michele Migliore

    (University of Milan
    Yale University School of Medicine
    Institute of Biophysics, National Research Council)

  • Armen Saghatelyan

    (Cellular Neurobiology Unit,Institut Universitaire en santé mentale de Québec
    Université Laval)

Abstract

Adult-born neurons adjust olfactory bulb (OB) network functioning in response to changing environmental conditions by the formation, retraction and/or stabilization of new synaptic contacts. While some changes in the odour environment are rapid, the synaptogenesis of adult-born neurons occurs over a longer time scale. It remains unknown how the bulbar network functions when rapid and persistent changes in environmental conditions occur but when new synapses have not been formed. Here we reveal a new form of structural remodelling where mature spines of adult-born but not early-born neurons relocate in an activity-dependent manner. Principal cell activity induces directional growth of spine head filopodia (SHF) followed by spine relocation. Principal cell-derived glutamate and BDNF regulate SHF motility and directional spine relocation, respectively; and spines with SHF are selectively preserved following sensory deprivation. Our three-dimensional model suggests that spine relocation allows fast reorganization of OB network with functional consequences for odour information processing.

Suggested Citation

  • Vincent Breton-Provencher & Karen Bakhshetyan & Delphine Hardy & Rodrigo Roberto Bammann & Francesco Cavarretta & Marina Snapyan & Daniel Côté & Michele Migliore & Armen Saghatelyan, 2016. "Principal cell activity induces spine relocation of adult-born interneurons in the olfactory bulb," Nature Communications, Nature, vol. 7(1), pages 1-16, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12659
    DOI: 10.1038/ncomms12659
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