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A strategy to discover new organizers identifies a putative heart organizer

Author

Listed:
  • Claire Anderson

    (University College London)

  • Mohsin A. F. Khan

    (University College London
    Present address: Heart Failure Research Center, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, Netherlands)

  • Frances Wong

    (The Roslin Institute, University of Edinburgh, Easter Bush)

  • Tatiana Solovieva

    (University College London)

  • Nidia M. M. Oliveira

    (University College London)

  • Richard A. Baldock

    (Biomedical Systems Analysis Section, MRC Human Genetics Unit, IGMM, University of Edinburgh)

  • Cheryll Tickle

    (University of Bath)

  • Dave W. Burt

    (The Roslin Institute, University of Edinburgh, Easter Bush)

  • Claudio D. Stern

    (University College London)

Abstract

Organizers are regions of the embryo that can both induce new fates and impart pattern on other regions. So far, surprisingly few organizers have been discovered, considering the number of patterned tissue types generated during development. This may be because their discovery has relied on transplantation and ablation experiments. Here we describe a new approach, using chick embryos, to discover organizers based on a common gene expression signature, and use it to uncover the anterior intestinal portal (AIP) endoderm as a putative heart organizer. We show that the AIP can induce cardiac identity from non-cardiac mesoderm and that it can pattern this by specifying ventricular and suppressing atrial regional identity. We also uncover some of the signals responsible. The method holds promise as a tool to discover other novel organizers acting during development.

Suggested Citation

  • Claire Anderson & Mohsin A. F. Khan & Frances Wong & Tatiana Solovieva & Nidia M. M. Oliveira & Richard A. Baldock & Cheryll Tickle & Dave W. Burt & Claudio D. Stern, 2016. "A strategy to discover new organizers identifies a putative heart organizer," Nature Communications, Nature, vol. 7(1), pages 1-9, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12656
    DOI: 10.1038/ncomms12656
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    Cited by:

    1. Eudald Pascual-Carreras & Marta Marín-Barba & Sergio Castillo-Lara & Pablo Coronel-Córdoba & Marta Silvia Magri & Grant N. Wheeler & Jose Luis Gómez-Skarmeta & Josep F. Abril & Emili Saló & Teresa Ade, 2023. "Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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