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Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates

Author

Listed:
  • Vida Chitsazzadeh

    (University of Texas MD Anderson Cancer Center Houston
    University of Texas MD Anderson Cancer Center Houston)

  • Cristian Coarfa

    (Baylor College of Medicine)

  • Jennifer A. Drummond

    (Human Genome Sequencing Center, Baylor College of Medicine)

  • Tri Nguyen

    (Northwest Diagnostic Clinic)

  • Aaron Joseph

    (Skin and Laser Surgery Associates)

  • Suneel Chilukuri

    (Bellaire Dermatology)

  • Elizabeth Charpiot

    (Bellaire Dermatology)

  • Charles H. Adelmann

    (University of Texas MD Anderson Cancer Center Houston
    University of Texas MD Anderson Cancer Center Houston)

  • Grace Ching

    (University of Texas MD Anderson Cancer Center Houston
    University of Texas MD Anderson Cancer Center Houston)

  • Tran N. Nguyen

    (University of Texas MD Anderson Cancer Center Houston)

  • Courtney Nicholas

    (University of Texas MD Anderson Cancer Center Houston)

  • Valencia D. Thomas

    (University of Texas MD Anderson Cancer Center Houston)

  • Michael Migden

    (University of Texas MD Anderson Cancer Center Houston)

  • Deborah MacFarlane

    (University of Texas MD Anderson Cancer Center Houston)

  • Erika Thompson

    (Sequencing and Microarray Facility, University of Texas MD Anderson Cancer Center Houston,)

  • Jianjun Shen

    (Next Generation Sequencing Facility, Smithville, University of Texas MD Anderson Cancer Center Houston,)

  • Yoko Takata

    (Next Generation Sequencing Facility, Smithville, University of Texas MD Anderson Cancer Center Houston,)

  • Kayla McNiece

    (University of Texas Medical School at Houston)

  • Maxim A. Polansky

    (University of Texas Medical School at Houston)

  • Hussein A. Abbas

    (University of Texas MD Anderson Cancer Center Houston)

  • Kimal Rajapakshe

    (Baylor College of Medicine)

  • Adam Gower

    (Boston University School of Medicine)

  • Avrum Spira

    (Boston University School of Medicine)

  • Kyle R. Covington

    (Baylor College of Medicine
    Human Genome Sequencing Center, Baylor College of Medicine)

  • Weimin Xiao

    (Department of Biology and Biochemistry University of Houston)

  • Preethi Gunaratne

    (Department of Biology and Biochemistry University of Houston)

  • Curtis Pickering

    (University of Texas MD Anderson Cancer Center Houston)

  • Mitchell Frederick

    (University of Texas MD Anderson Cancer Center Houston)

  • Jeffrey N. Myers

    (University of Texas MD Anderson Cancer Center Houston)

  • Li Shen

    (University of Texas MD Anderson Cancer Center Houston)

  • Hui Yao

    (University of Texas MD Anderson Cancer Center Houston)

  • Xiaoping Su

    (University of Texas MD Anderson Cancer Center Houston)

  • Ronald P. Rapini

    (University of Texas MD Anderson Cancer Center Houston
    University of Texas Medical School at Houston)

  • David A. Wheeler

    (Baylor College of Medicine
    Human Genome Sequencing Center, Baylor College of Medicine)

  • Ernest T. Hawk

    (University of Texas MD Anderson Cancer Center Houston)

  • Elsa R. Flores

    (University of Texas MD Anderson Cancer Center Houston)

  • Kenneth Y. Tsai

    (University of Texas MD Anderson Cancer Center Houston
    University of Texas MD Anderson Cancer Center Houston)

Abstract

Cutaneous squamous cell carcinoma (cuSCC) comprises 15–20% of all skin cancers, accounting for over 700,000 cases in USA annually. Most cuSCC arise in association with a distinct precancerous lesion, the actinic keratosis (AK). To identify potential targets for molecularly targeted chemoprevention, here we perform integrated cross-species genomic analysis of cuSCC development through the preneoplastic AK stage using matched human samples and a solar ultraviolet radiation-driven Hairless mouse model. We identify the major transcriptional drivers of this progression sequence, showing that the key genomic changes in cuSCC development occur in the normal skin to AK transition. Our data validate the use of this ultraviolet radiation-driven mouse cuSCC model for cross-species analysis and demonstrate that cuSCC bears deep molecular similarities to multiple carcinogen-driven SCCs from diverse sites, suggesting that cuSCC may serve as an effective, accessible model for multiple SCC types and that common treatment and prevention strategies may be feasible.

Suggested Citation

  • Vida Chitsazzadeh & Cristian Coarfa & Jennifer A. Drummond & Tri Nguyen & Aaron Joseph & Suneel Chilukuri & Elizabeth Charpiot & Charles H. Adelmann & Grace Ching & Tran N. Nguyen & Courtney Nicholas , 2016. "Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates," Nature Communications, Nature, vol. 7(1), pages 1-17, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12601
    DOI: 10.1038/ncomms12601
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    Cited by:

    1. Sabrina Schütz & Llorenç Solé-Boldo & Carlota Lucena-Porcel & Jochen Hoffmann & Alexander Brobeil & Anke S. Lonsdorf & Manuel Rodríguez-Paredes & Frank Lyko, 2023. "Functionally distinct cancer-associated fibroblast subpopulations establish a tumor promoting environment in squamous cell carcinoma," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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