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LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression

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  • Zhen-zhen Chen

    (School of Life Sciences, Zhengzhou University)

  • Lan Huang

    (The First Affiliated Hospital, Zhengzhou University)

  • Ya-hong Wu

    (School of Life Sciences, Zhengzhou University)

  • Wen-jie Zhai

    (School of Life Sciences, Zhengzhou University)

  • Ping-ping Zhu

    (School of Life Sciences, University of Science and Technology of China)

  • Yan-feng Gao

    (School of Life Sciences, Zhengzhou University
    Collaborative Innovation Center of New Drug Research and Safety Evaluation)

Abstract

Liver cancer has a tendency to develop asymptomatically in patients, so most patients are diagnosed at a later stage. Accumulating evidence implicates that liver tumour-initiating cells (TICs) as being responsible for liver cancer initiation and recurrence. However, the molecular mechanism of liver TIC self-renewal is poorly understood. Here we discover that a long noncoding RNA (lncRNA) termed LncSox4 is highly expressed in hepatocellular carcinoma (HCC) tissues and in liver TICs. We find that LncSox4 is required for liver TIC self-renewal and tumour initiation. LncSox4 interacts with and recruits Stat3 to the Sox4 promoter to initiate the expression of Sox4, which is highly expressed in liver TICs and required for liver TIC self-renewal. The expression level of Sox4 correlates with HCC development, clinical severity and prognosis of patients. Altogether, we find that LncSox4 is highly expressed in liver TICs and is required for their self-renewal.

Suggested Citation

  • Zhen-zhen Chen & Lan Huang & Ya-hong Wu & Wen-jie Zhai & Ping-ping Zhu & Yan-feng Gao, 2016. "LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression," Nature Communications, Nature, vol. 7(1), pages 1-13, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12598
    DOI: 10.1038/ncomms12598
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    Cited by:

    1. Zhenzhen Chen & Qiankun He & Tiankun Lu & Jiayi Wu & Gaoli Shi & Luyun He & Hong Zong & Benyu Liu & Pingping Zhu, 2023. "mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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