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Regulation of monocyte cell fate by blood vessels mediated by Notch signalling

Author

Listed:
  • Jaba Gamrekelashvili

    (Hannover Medical School)

  • Roberto Giagnorio

    (Hannover Medical School
    Integrated Research and Treatment Center Transplantation, Hannover Medical School)

  • Jasmin Jussofie

    (Hannover Medical School
    Present address: Department of Cardiology, Universitätsklinikum Düsseldorf, D 40225 Düsseldorf, Germany.)

  • Oliver Soehnlein

    (Institute for Cardiovascular Prevention, Ludwig-Maximilians-University
    Academic Medical Center, Amsterdam University
    German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance)

  • Johan Duchene

    (Institute for Cardiovascular Prevention, Ludwig-Maximilians-University)

  • Carlos G. Briseño

    (Washington University in St Louis, School of Medicine)

  • Saravana K. Ramasamy

    (Max Planck Institute for Molecular Biomedicine)

  • Kashyap Krishnasamy

    (Hannover Medical School)

  • Anne Limbourg

    (Hand and Reconstructive Surgery, Hannover Medical School)

  • Christine Häger

    (Hannover Medical School
    Present address: Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover D 30625, Germany.)

  • Tamar Kapanadze

    (Hannover Medical School
    Integrated Research and Treatment Center Transplantation, Hannover Medical School)

  • Chieko Ishifune

    (Graduate School of Medicine, Tokushima University)

  • Rabea Hinkel

    (Institute for Cardiovascular Prevention, Ludwig-Maximilians-University
    Medizinische Klinik I, Klinikum Rechts der Isar, Technical University of Munich)

  • Freddy Radtke

    (Ecole Polytechnique Fédérale de Lausanne, School of Life Sciences, ISREC)

  • Lothar J. Strobl

    (Research Unit Gene Vectors, Helmholtz Zentrum München, German Research Center for Environment and Health (GmbH))

  • Ursula Zimber-Strobl

    (Research Unit Gene Vectors, Helmholtz Zentrum München, German Research Center for Environment and Health (GmbH))

  • L. Christian Napp

    (Hannover Medical School)

  • Johann Bauersachs

    (Hannover Medical School)

  • Hermann Haller

    (Hannover Medical School)

  • Koji Yasutomo

    (Graduate School of Medicine, Tokushima University)

  • Christian Kupatt

    (Institute for Cardiovascular Prevention, Ludwig-Maximilians-University
    Medizinische Klinik I, Klinikum Rechts der Isar, Technical University of Munich)

  • Kenneth M. Murphy

    (Washington University in St Louis, School of Medicine
    Howard Hughes Medical Institute, Washington University in St Louis, School of Medicine)

  • Ralf H. Adams

    (Max Planck Institute for Molecular Biomedicine)

  • Christian Weber

    (Institute for Cardiovascular Prevention, Ludwig-Maximilians-University
    Cardiovascular Research Institute Maastricht (CARIM))

  • Florian P. Limbourg

    (Hannover Medical School
    Integrated Research and Treatment Center Transplantation, Hannover Medical School)

Abstract

A population of monocytes, known as Ly6Clo monocytes, patrol blood vessels by crawling along the vascular endothelium. Here we show that endothelial cells control their origin through Notch signalling. Using combinations of conditional genetic deletion strategies and cell-fate tracking experiments we show that Notch2 regulates conversion of Ly6Chi monocytes into Ly6Clo monocytes in vivo and in vitro, thereby regulating monocyte cell fate under steady-state conditions. This process is controlled by Notch ligand delta-like 1 (Dll1) expressed by a population of endothelial cells that constitute distinct vascular niches in the bone marrow and spleen in vivo, while culture on recombinant DLL1 induces monocyte conversion in vitro. Thus, blood vessels regulate monocyte conversion, a form of committed myeloid cell fate regulation.

Suggested Citation

  • Jaba Gamrekelashvili & Roberto Giagnorio & Jasmin Jussofie & Oliver Soehnlein & Johan Duchene & Carlos G. Briseño & Saravana K. Ramasamy & Kashyap Krishnasamy & Anne Limbourg & Christine Häger & Tamar, 2016. "Regulation of monocyte cell fate by blood vessels mediated by Notch signalling," Nature Communications, Nature, vol. 7(1), pages 1-15, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12597
    DOI: 10.1038/ncomms12597
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    Cited by:

    1. Mayra Cruz Tleugabulova & Sandra P. Melo & Aaron Wong & Alexander Arlantico & Meizi Liu & Joshua D. Webster & Julia Lau & Antonie Lechner & Basak Corak & Jonathan J. Hodgins & Venkata S. Garlapati & M, 2024. "Induction of a distinct macrophage population and protection from lung injury and fibrosis by Notch2 blockade," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Feiyang Ma & Olesya Plazyo & Allison C. Billi & Lam C. Tsoi & Xianying Xing & Rachael Wasikowski & Mehrnaz Gharaee-Kermani & Grace Hile & Yanyun Jiang & Paul W. Harms & Enze Xing & Joseph Kirma & Jing, 2023. "Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Julie Rondeaux & Déborah Groussard & Sylvanie Renet & Virginie Tardif & Anaïs Dumesnil & Alphonse Chu & Léa Maria & Théo Lemarcis & Manon Valet & Jean-Paul Henry & Zina Badji & Claire Vézier & Delphin, 2023. "Ezh2 emerges as an epigenetic checkpoint regulator during monocyte differentiation limiting cardiac dysfunction post-MI," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Susanne Fleig & Tamar Kapanadze & Jeremiah Bernier-Latmani & Julia K. Lill & Tania Wyss & Jaba Gamrekelashvili & Dustin Kijas & Bin Liu & Anne M. Hüsing & Esther Bovay & Adan Chari Jirmo & Stephan Hal, 2022. "Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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