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Sleep recalibrates homeostatic and associative synaptic plasticity in the human cortex

Author

Listed:
  • Marion Kuhn

    (University Medical Center Freiburg)

  • Elias Wolf

    (University Medical Center Freiburg)

  • Jonathan G. Maier

    (University Medical Center Freiburg)

  • Florian Mainberger

    (University Medical Center Freiburg)

  • Bernd Feige

    (University Medical Center Freiburg)

  • Hanna Schmid

    (University Medical Center Freiburg)

  • Jan Bürklin

    (University Medical Center Freiburg)

  • Sarah Maywald

    (University Medical Center Freiburg)

  • Volker Mall

    (Technische Universität München)

  • Nikolai H. Jung

    (Technische Universität München)

  • Janine Reis

    (University Medical Center Freiburg)

  • Kai Spiegelhalder

    (University Medical Center Freiburg)

  • Stefan Klöppel

    (University Medical Center Freiburg
    University Medical Center Freiburg)

  • Annette Sterr

    (University of Surrey)

  • Anne Eckert

    (Neurobiology Lab for Brain Aging and Mental Health, Transfaculty Research Platform University of Basel, Psychiatric University Clinics Basel)

  • Dieter Riemann

    (University Medical Center Freiburg)

  • Claus Normann

    (University Medical Center Freiburg)

  • Christoph Nissen

    (University Medical Center Freiburg)

Abstract

Sleep is ubiquitous in animals and humans, but its function remains to be further determined. The synaptic homeostasis hypothesis of sleep–wake regulation proposes a homeostatic increase in net synaptic strength and cortical excitability along with decreased inducibility of associative synaptic long-term potentiation (LTP) due to saturation after sleep deprivation. Here we use electrophysiological, behavioural and molecular indices to non-invasively study net synaptic strength and LTP-like plasticity in humans after sleep and sleep deprivation. We demonstrate indices of increased net synaptic strength (TMS intensity to elicit a predefined amplitude of motor-evoked potential and EEG theta activity) and decreased LTP-like plasticity (paired associative stimulation induced change in motor-evoked potential and memory formation) after sleep deprivation. Changes in plasma BDNF are identified as a potential mechanism. Our study indicates that sleep recalibrates homeostatic and associative synaptic plasticity, believed to be the neural basis for adaptive behaviour, in humans.

Suggested Citation

  • Marion Kuhn & Elias Wolf & Jonathan G. Maier & Florian Mainberger & Bernd Feige & Hanna Schmid & Jan Bürklin & Sarah Maywald & Volker Mall & Nikolai H. Jung & Janine Reis & Kai Spiegelhalder & Stefan , 2016. "Sleep recalibrates homeostatic and associative synaptic plasticity in the human cortex," Nature Communications, Nature, vol. 7(1), pages 1-9, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12455
    DOI: 10.1038/ncomms12455
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