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Long-range movement of large mechanically interlocked DNA nanostructures

Author

Listed:
  • Jonathan List

    (Technische Universität München, Am Coulombwall 4a)

  • Elisabeth Falgenhauer

    (Technische Universität München, Am Coulombwall 4a)

  • Enzo Kopperger

    (Technische Universität München, Am Coulombwall 4a)

  • Günther Pardatscher

    (Technische Universität München, Am Coulombwall 4a)

  • Friedrich C. Simmel

    (Technische Universität München, Am Coulombwall 4a)

Abstract

Interlocked molecules such as catenanes and rotaxanes, connected only via mechanical bonds have the ability to perform large-scale sliding and rotational movements, making them attractive components for the construction of artificial molecular machines and motors. We here demonstrate the realization of large, rigid rotaxane structures composed of DNA origami subunits. The structures can be easily modified to carry a molecular cargo or nanoparticles. By using multiple axle modules, rotaxane constructs are realized with axle lengths of up to 355 nm and a fuel/anti-fuel mechanism is employed to switch the rotaxanes between a mobile and a fixed state. We also create extended pseudo-rotaxanes, in which origami rings can slide along supramolecular DNA filaments over several hundreds of nanometres. The rings can be actively moved and tracked using atomic force microscopy.

Suggested Citation

  • Jonathan List & Elisabeth Falgenhauer & Enzo Kopperger & Günther Pardatscher & Friedrich C. Simmel, 2016. "Long-range movement of large mechanically interlocked DNA nanostructures," Nature Communications, Nature, vol. 7(1), pages 1-7, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12414
    DOI: 10.1038/ncomms12414
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    Cited by:

    1. Eva Bertosin & Christopher M. Maffeo & Thomas Drexler & Maximilian N. Honemann & Aleksei Aksimentiev & Hendrik Dietz, 2021. "A nanoscale reciprocating rotary mechanism with coordinated mobility control," Nature Communications, Nature, vol. 12(1), pages 1-11, December.

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