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Total synthesis of teixobactin

Author

Listed:
  • Kang Jin

    (State Key Lab of Synthetic Chemistry, The University of Hong Kong)

  • Iek Hou Sam

    (State Key Lab of Synthetic Chemistry, The University of Hong Kong)

  • Kathy Hiu Laam Po

    (The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China)

  • Du’an Lin

    (State Key Lab of Synthetic Chemistry, The University of Hong Kong)

  • Ebrahim H. Ghazvini Zadeh

    (University of Central Florida)

  • Sheng Chen

    (The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China)

  • Yu Yuan

    (University of Central Florida)

  • Xuechen Li

    (State Key Lab of Synthetic Chemistry, The University of Hong Kong)

Abstract

To cope with the global bacterial multidrug resistance, scientific communities have devoted significant efforts to develop novel antibiotics, particularly those with new modes of actions. Teixobactin, recently isolated from uncultured bacteria, is considered as a promising first-in-class drug candidate for clinical development. Herein, we report its total synthesis by a highly convergent Ser ligation approach and this strategy allows us to prepare several analogues of the natural product.

Suggested Citation

  • Kang Jin & Iek Hou Sam & Kathy Hiu Laam Po & Du’an Lin & Ebrahim H. Ghazvini Zadeh & Sheng Chen & Yu Yuan & Xuechen Li, 2016. "Total synthesis of teixobactin," Nature Communications, Nature, vol. 7(1), pages 1-6, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12394
    DOI: 10.1038/ncomms12394
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