IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v7y2016i1d10.1038_ncomms12388.html
   My bibliography  Save this article

Self-organized centripetal movement of corneal epithelium in the absence of external cues

Author

Listed:
  • Erwin P. Lobo

    (School of Mathematics and Statistics)

  • Naomi C. Delic

    (Discipline of Dermatology, Bosch Institute, Charles Perkins Centre, University of Sydney
    Immune Imaging Program, Centenary Institute for Cancer Medicine and Cell Biology)

  • Alex Richardson

    (School of Medical Sciences, University of New South Wales)

  • Vanisri Raviraj

    (Discipline of Dermatology, Bosch Institute, Charles Perkins Centre, University of Sydney
    Immune Imaging Program, Centenary Institute for Cancer Medicine and Cell Biology)

  • Gary M. Halliday

    (Discipline of Dermatology, Bosch Institute, Charles Perkins Centre, University of Sydney)

  • Nick Di Girolamo

    (School of Medical Sciences, University of New South Wales)

  • Mary R. Myerscough

    (School of Mathematics and Statistics)

  • J. Guy Lyons

    (Discipline of Dermatology, Bosch Institute, Charles Perkins Centre, University of Sydney
    Immune Imaging Program, Centenary Institute for Cancer Medicine and Cell Biology
    Sydney Head and Neck Cancer Institute, Cancer Services, Royal Prince Alfred Hospital)

Abstract

Maintaining the structure of the cornea is essential for high-quality vision. In adult mammals, corneal epithelial cells emanate from stem cells in the limbus, driven by an unknown mechanism towards the centre of the cornea as cohesive clonal groups. Here we use complementary mathematical and biological models to show that corneal epithelial cells can self-organize into a cohesive, centripetal growth pattern in the absence of external physiological cues. Three conditions are required: a circumferential location of stem cells, a limited number of cell divisions and mobility in response to population pressure. We have used these complementary models to provide explanations for the increased rate of centripetal migration caused by wounding and the potential for stem cell leakage to account for stable transplants derived from central corneal tissue, despite the predominantly limbal location of stem cells.

Suggested Citation

  • Erwin P. Lobo & Naomi C. Delic & Alex Richardson & Vanisri Raviraj & Gary M. Halliday & Nick Di Girolamo & Mary R. Myerscough & J. Guy Lyons, 2016. "Self-organized centripetal movement of corneal epithelium in the absence of external cues," Nature Communications, Nature, vol. 7(1), pages 1-8, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12388
    DOI: 10.1038/ncomms12388
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms12388
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms12388?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12388. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.