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Healthy ageing of cloned sheep

Author

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  • K. D. Sinclair

    (Schools of Biosciences (KDS, CGG, PAF, J-HL, AJR, IC, KHSC), School of Veterinary Medicine and Science (SAC, DSG), University of Nottingham)

  • S. A. Corr

    (Schools of Biosciences (KDS, CGG, PAF, J-HL, AJR, IC, KHSC), School of Veterinary Medicine and Science (SAC, DSG), University of Nottingham)

  • C. G. Gutierrez

    (Schools of Biosciences (KDS, CGG, PAF, J-HL, AJR, IC, KHSC), School of Veterinary Medicine and Science (SAC, DSG), University of Nottingham
    Universidad Nacional Autonoma de Mexico, Facultad de Medicina Veterinaria)

  • P. A. Fisher

    (Schools of Biosciences (KDS, CGG, PAF, J-HL, AJR, IC, KHSC), School of Veterinary Medicine and Science (SAC, DSG), University of Nottingham)

  • J.-H. Lee

    (Schools of Biosciences (KDS, CGG, PAF, J-HL, AJR, IC, KHSC), School of Veterinary Medicine and Science (SAC, DSG), University of Nottingham
    Present address: Department of Animal Bioscience, Institute of Agriculture & Life Science, College of Agriculture & Life Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea)

  • A. J. Rathbone

    (Schools of Biosciences (KDS, CGG, PAF, J-HL, AJR, IC, KHSC), School of Veterinary Medicine and Science (SAC, DSG), University of Nottingham)

  • I. Choi

    (Schools of Biosciences (KDS, CGG, PAF, J-HL, AJR, IC, KHSC), School of Veterinary Medicine and Science (SAC, DSG), University of Nottingham
    Present address: Division of Animal and Dairy Sciences, College of Agriculture and Life Sciences, Chungnam National University, Daejeon 34134, Republic of Korea)

  • K. H. S. Campbell

    (Schools of Biosciences (KDS, CGG, PAF, J-HL, AJR, IC, KHSC), School of Veterinary Medicine and Science (SAC, DSG), University of Nottingham)

  • D. S. Gardner

    (Schools of Biosciences (KDS, CGG, PAF, J-HL, AJR, IC, KHSC), School of Veterinary Medicine and Science (SAC, DSG), University of Nottingham)

Abstract

The health of cloned animals generated by somatic-cell nuclear transfer (SCNT) has been of concern since its inception; however, there are no detailed assessments of late-onset, non-communicable diseases. Here we report that SCNT has no obvious detrimental long-term health effects in a cohort of 13 cloned sheep. We perform musculoskeletal assessments, metabolic tests and blood pressure measurements in 13 aged (7–9 years old) cloned sheep, including four derived from the cell line that gave rise to Dolly. We also perform radiological examinations of all main joints, including the knees, the joint most affected by osteoarthritis in Dolly, and compare all health parameters to groups of 5-and 6-year-old sheep, and published reference ranges. Despite their advanced age, these clones are euglycaemic, insulin sensitive and normotensive. Importantly, we observe no clinical signs of degenerative joint disease apart from mild, or in one case moderate, osteoarthritis in some animals. Our study is the first to assess the long-term health outcomes of SCNT in large animals.

Suggested Citation

  • K. D. Sinclair & S. A. Corr & C. G. Gutierrez & P. A. Fisher & J.-H. Lee & A. J. Rathbone & I. Choi & K. H. S. Campbell & D. S. Gardner, 2016. "Healthy ageing of cloned sheep," Nature Communications, Nature, vol. 7(1), pages 1-10, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12359
    DOI: 10.1038/ncomms12359
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    Cited by:

    1. Hopp, Christian & Hoover, Gary A., 2017. "How prevalent is academic misconduct in management research?," Journal of Business Research, Elsevier, vol. 80(C), pages 73-81.

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