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Early programming of the oocyte epigenome temporally controls late prophase I transcription and chromatin remodelling

Author

Listed:
  • Paulo Navarro-Costa

    (and Center for Biomedical Research, Universidade do Algarve, Campus de Gambelas
    Instituto Gulbenkian de Ciência)

  • Alicia McCarthy

    (University at Albany SUNY)

  • Pedro Prudêncio

    (and Center for Biomedical Research, Universidade do Algarve, Campus de Gambelas
    Instituto Gulbenkian de Ciência)

  • Christina Greer

    (Albert Einstein College of Medicine)

  • Leonardo G. Guilgur

    (and Center for Biomedical Research, Universidade do Algarve, Campus de Gambelas
    Instituto Gulbenkian de Ciência)

  • Jörg D. Becker

    (Instituto Gulbenkian de Ciência)

  • Julie Secombe

    (Albert Einstein College of Medicine)

  • Prashanth Rangan

    (University at Albany SUNY)

  • Rui G. Martinho

    (and Center for Biomedical Research, Universidade do Algarve, Campus de Gambelas
    Instituto Gulbenkian de Ciência)

Abstract

Oocytes are arrested for long periods of time in the prophase of the first meiotic division (prophase I). As chromosome condensation poses significant constraints to gene expression, the mechanisms regulating transcriptional activity in the prophase I-arrested oocyte are still not entirely understood. We hypothesized that gene expression during the prophase I arrest is primarily epigenetically regulated. Here we comprehensively define the Drosophila female germ line epigenome throughout oogenesis and show that the oocyte has a unique, dynamic and remarkably diversified epigenome characterized by the presence of both euchromatic and heterochromatic marks. We observed that the perturbation of the oocyte’s epigenome in early oogenesis, through depletion of the dKDM5 histone demethylase, results in the temporal deregulation of meiotic transcription and affects female fertility. Taken together, our results indicate that the early programming of the oocyte epigenome primes meiotic chromatin for subsequent functions in late prophase I.

Suggested Citation

  • Paulo Navarro-Costa & Alicia McCarthy & Pedro Prudêncio & Christina Greer & Leonardo G. Guilgur & Jörg D. Becker & Julie Secombe & Prashanth Rangan & Rui G. Martinho, 2016. "Early programming of the oocyte epigenome temporally controls late prophase I transcription and chromatin remodelling," Nature Communications, Nature, vol. 7(1), pages 1-15, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12331
    DOI: 10.1038/ncomms12331
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    Cited by:

    1. Marianne Yoth & Stéphanie Maupetit-Méhouas & Abdou Akkouche & Nathalie Gueguen & Benjamin Bertin & Silke Jensen & Emilie Brasset, 2023. "Reactivation of a somatic errantivirus and germline invasion in Drosophila ovaries," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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