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SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3–LAR adhesion

Author

Listed:
  • Eunkyung Lie

    (Korea Advanced Institute for Science and Technology)

  • Ji Seung Ko

    (College of Life Science and Biotechnology, Yonsei University)

  • Su-Yeon Choi

    (Center for Synaptic Brain Dysfunctions, Institute for Basic Science)

  • Junyeop Daniel Roh

    (Center for Synaptic Brain Dysfunctions, Institute for Basic Science)

  • Yi Sul Cho

    (School of Dentistry, Kyungpook National University)

  • Ran Noh

    (Center for Cognition and Sociality, Institute for Basic Science)

  • Doyoun Kim

    (Center for Synaptic Brain Dysfunctions, Institute for Basic Science)

  • Yan Li

    (Center for Synaptic Brain Dysfunctions, Institute for Basic Science)

  • Hyeyeon Kang

    (Yonsei University College of Medicine)

  • Tae-Yong Choi

    (Seoul National University School of Dentistry)

  • Jungyong Nam

    (Korea Advanced Institute for Science and Technology)

  • Won Mah

    (School of Dentistry, Kyungpook National University)

  • Dongmin Lee

    (Biomedical Science, College of Medicine, Korea University)

  • Seong-Gyu Lee

    (Graduate School of Medical Science and Engineering, Korea Advanced Institute for Science and Technology)

  • Ho Min Kim

    (Graduate School of Medical Science and Engineering, Korea Advanced Institute for Science and Technology)

  • Hyun Kim

    (Biomedical Science, College of Medicine, Korea University)

  • Se-Young Choi

    (Seoul National University School of Dentistry)

  • Ji Won Um

    (Yonsei University College of Medicine)

  • Myoung-Goo Kang

    (Center for Cognition and Sociality, Institute for Basic Science
    Graduate School of Medical Science and Engineering, Korea Advanced Institute for Science and Technology)

  • Yong Chul Bae

    (School of Dentistry, Kyungpook National University)

  • Jaewon Ko

    (College of Life Science and Biotechnology, Yonsei University)

  • Eunjoon Kim

    (Korea Advanced Institute for Science and Technology
    Center for Synaptic Brain Dysfunctions, Institute for Basic Science)

Abstract

Synaptic adhesion molecules regulate various aspects of synapse development, function and plasticity. These functions mainly involve trans-synaptic interactions and positive regulations, whereas cis-interactions and negative regulation are less understood. Here we report that SALM4, a member of the SALM/Lrfn family of synaptic adhesion molecules, suppresses excitatory synapse development through cis inhibition of SALM3, another SALM family protein with synaptogenic activity. Salm4-mutant (Salm4−/−) mice show increased excitatory synapse numbers in the hippocampus. SALM4 cis-interacts with SALM3, inhibits trans-synaptic SALM3 interaction with presynaptic LAR family receptor tyrosine phosphatases and suppresses SALM3-dependent presynaptic differentiation. Importantly, deletion of Salm3 in Salm4−/− mice (Salm3−/−; Salm4−/−) normalizes the increased excitatory synapse number. These results suggest that SALM4 negatively regulates excitatory synapses via cis inhibition of the trans-synaptic SALM3–LAR adhesion.

Suggested Citation

  • Eunkyung Lie & Ji Seung Ko & Su-Yeon Choi & Junyeop Daniel Roh & Yi Sul Cho & Ran Noh & Doyoun Kim & Yan Li & Hyeyeon Kang & Tae-Yong Choi & Jungyong Nam & Won Mah & Dongmin Lee & Seong-Gyu Lee & Ho M, 2016. "SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3–LAR adhesion," Nature Communications, Nature, vol. 7(1), pages 1-15, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12328
    DOI: 10.1038/ncomms12328
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