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Plexins function in epithelial repair in both Drosophila and zebrafish

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  • Sa Kan Yoo

    (University of California
    The Miller Institute, University of California
    Physiological Genetics Laboratory, RIKEN, 2-2-3 Minatojima-minamimachi)

  • Heath G. Pascoe

    (University of Texas Southwestern Medical Center)

  • Telmo Pereira

    (Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa
    CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Universidade NOVA de Lisboa, 130)

  • Shu Kondo

    (Genetic Strains Research Center, National Institute of Genetics, 1111 Yata)

  • Antonio Jacinto

    (CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Universidade NOVA de Lisboa, 130)

  • Xuewu Zhang

    (University of Texas Southwestern Medical Center)

  • Iswar K. Hariharan

    (University of California)

Abstract

In most multicellular organisms, homeostasis is contingent upon maintaining epithelial integrity. When unanticipated insults breach epithelial barriers, dormant programmes of tissue repair are immediately activated. However, many of the mechanisms that repair damaged epithelia remain poorly characterized. Here we describe a role for Plexin A (PlexA), a protein with particularly well-characterized roles in axonal pathfinding, in the healing of damaged epithelia in Drosophila. Semaphorins, which are PlexA ligands, also regulate tissue repair. We show that Drosophila PlexA has GAP activity for the Rap1 GTPase, which is known to regulate the stability of adherens junctions. Our observations suggest that the inhibition of Rap1 activity by PlexA in damaged Drosophila epithelia allows epithelial remodelling, thus facilitating wound repair. We also demonstrate a role for Plexin A1, a zebrafish orthologue of Drosophila PlexA, in epithelial repair in zebrafish tail fins. Thus, plexins function in epithelial wound healing in diverse taxa.

Suggested Citation

  • Sa Kan Yoo & Heath G. Pascoe & Telmo Pereira & Shu Kondo & Antonio Jacinto & Xuewu Zhang & Iswar K. Hariharan, 2016. "Plexins function in epithelial repair in both Drosophila and zebrafish," Nature Communications, Nature, vol. 7(1), pages 1-12, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12282
    DOI: 10.1038/ncomms12282
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