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Spatial clustering of tuning in mouse primary visual cortex

Author

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  • Dario L. Ringach

    (David Geffen School of Medicine, University of California
    University of California)

  • Patrick J. Mineault

    (David Geffen School of Medicine, University of California)

  • Elaine Tring

    (David Geffen School of Medicine, University of California)

  • Nicholas D. Olivas

    (David Geffen School of Medicine, University of California)

  • Pablo Garcia-Junco-Clemente

    (David Geffen School of Medicine, University of California
    Present address: Instituto de Biomedicina de Sevilla, IBiS, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla and Departamento de Fisiología Médica y Biofísica, Universidad de Sevilla, and CIBERNED)

  • Joshua T. Trachtenberg

    (David Geffen School of Medicine, University of California)

Abstract

The primary visual cortex of higher mammals is organized into two-dimensional maps, where the preference of cells for stimulus parameters is arranged regularly on the cortical surface. In contrast, the preference of neurons in the rodent appears to be arranged randomly, in what is termed a salt-and-pepper map. Here we revisited the spatial organization of receptive fields in mouse primary visual cortex by measuring the tuning of pyramidal neurons in the joint orientation and spatial frequency domain. We found that the similarity of tuning decreases as a function of cortical distance, revealing a weak but statistically significant spatial clustering. Clustering was also observed across different cortical depths, consistent with a columnar organization. Thus, the mouse visual cortex is not strictly a salt-and-pepper map. At least on a local scale, it resembles a degraded version of the organization seen in higher mammals, hinting at a possible common origin.

Suggested Citation

  • Dario L. Ringach & Patrick J. Mineault & Elaine Tring & Nicholas D. Olivas & Pablo Garcia-Junco-Clemente & Joshua T. Trachtenberg, 2016. "Spatial clustering of tuning in mouse primary visual cortex," Nature Communications, Nature, vol. 7(1), pages 1-9, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12270
    DOI: 10.1038/ncomms12270
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    Cited by:

    1. Jiashu Liu & Yingtian He & Andreanne Lavoie & Guy Bouvier & Bao-hua Liu, 2023. "A direction-selective cortico-brainstem pathway adaptively modulates innate behaviors," Nature Communications, Nature, vol. 14(1), pages 1-23, December.
    2. Elaine Tring & Konnie K. Duan & Dario L. Ringach, 2022. "ON/OFF domains shape receptive field structure in mouse visual cortex," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    3. Han Chin Wang & Amy M. LeMessurier & Daniel E. Feldman, 2022. "Tuning instability of non-columnar neurons in the salt-and-pepper whisker map in somatosensory cortex," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    4. Peichao Li & Anupam K. Garg & Li A. Zhang & Mohammad S. Rashid & Edward M. Callaway, 2022. "Cone opponent functional domains in primary visual cortex combine signals for color appearance mechanisms," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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