IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v7y2016i1d10.1038_ncomms12238.html
   My bibliography  Save this article

Molecular signatures of neural connectivity in the olfactory cortex

Author

Listed:
  • Assunta Diodato

    (Center for Interdisciplinary Research in Biology (CIRB), Collège de France, and CNRS, UMR 7241 and INSERM U1050)

  • Marion Ruinart de Brimont

    (Center for Interdisciplinary Research in Biology (CIRB), Collège de France, and CNRS, UMR 7241 and INSERM U1050)

  • Yeong Shin Yim

    (McGovern Institute for Brain Research, Massachusetts Institute of Technology)

  • Nicolas Derian

    (Sorbonne Universités, UPMC Univ Paris 06, INSERM U959, Immunology-Immunopathology-Immunotherapy (I3), and AP-HP, Clinical Investigation Center in Biotherapy)

  • Sandrine Perrin

    (École Normale Supérieure, Institut de Biologie de l’ENS, Plateforme Génomique, and INSERM U1024, CNRS UMR 8197)

  • Juliette Pouch

    (École Normale Supérieure, Institut de Biologie de l’ENS, Plateforme Génomique, and INSERM U1024, CNRS UMR 8197)

  • David Klatzmann

    (Sorbonne Universités, UPMC Univ Paris 06, INSERM U959, Immunology-Immunopathology-Immunotherapy (I3), and AP-HP, Clinical Investigation Center in Biotherapy)

  • Sonia Garel

    (École Normale Supérieure, Institut de Biologie de l’ENS, and INSERM U1024, CNRS UMR 8197)

  • Gloria B Choi

    (McGovern Institute for Brain Research, Massachusetts Institute of Technology)

  • Alexander Fleischmann

    (Center for Interdisciplinary Research in Biology (CIRB), Collège de France, and CNRS, UMR 7241 and INSERM U1050)

Abstract

The ability to target subclasses of neurons with defined connectivity is crucial for uncovering neural circuit functions. The olfactory (piriform) cortex is thought to generate odour percepts and memories, and odour information encoded in piriform is routed to target brain areas involved in multimodal sensory integration, cognition and motor control. However, it remains unknown if piriform outputs are spatially organized, and if distinct output channels are delineated by different gene expression patterns. Here we identify genes selectively expressed in different layers of the piriform cortex. Neural tracing experiments reveal that these layer-specific piriform genes mark different subclasses of neurons, which project to distinct target areas. Interestingly, these molecular signatures of connectivity are maintained in reeler mutant mice, in which neural positioning is scrambled. These results reveal that a predictive link between a neuron’s molecular identity and connectivity in this cortical circuit is determined independent of its spatial position.

Suggested Citation

  • Assunta Diodato & Marion Ruinart de Brimont & Yeong Shin Yim & Nicolas Derian & Sandrine Perrin & Juliette Pouch & David Klatzmann & Sonia Garel & Gloria B Choi & Alexander Fleischmann, 2016. "Molecular signatures of neural connectivity in the olfactory cortex," Nature Communications, Nature, vol. 7(1), pages 1-10, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12238
    DOI: 10.1038/ncomms12238
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms12238
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms12238?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Joseph D. Zak & Gautam Reddy & Vaibhav Konanur & Venkatesh N. Murthy, 2024. "Distinct information conveyed to the olfactory bulb by feedforward input from the nose and feedback from the cortex," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Camille Mazo & Antoine Nissant & Soham Saha & Enzo Peroni & Pierre-Marie Lledo & Gabriel Lepousez, 2022. "Long-range GABAergic projections contribute to cortical feedback control of sensory processing," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12238. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.