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SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability

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  • Lei Li

    (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), School of Basic Medical Sciences, Peking University Health Science Center)

  • Lan Shi

    (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), School of Basic Medical Sciences, Peking University Health Science Center)

  • Shangda Yang

    (2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University)

  • Ruorong Yan

    (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), School of Basic Medical Sciences, Peking University Health Science Center)

  • Di Zhang

    (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), School of Basic Medical Sciences, Peking University Health Science Center)

  • Jianguo Yang

    (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), School of Basic Medical Sciences, Peking University Health Science Center)

  • Lin He

    (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), School of Basic Medical Sciences, Peking University Health Science Center)

  • Wanjin Li

    (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), School of Basic Medical Sciences, Peking University Health Science Center)

  • Xia Yi

    (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), School of Basic Medical Sciences, Peking University Health Science Center)

  • Luyang Sun

    (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), School of Basic Medical Sciences, Peking University Health Science Center)

  • Jing Liang

    (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), School of Basic Medical Sciences, Peking University Health Science Center)

  • Zhongyi Cheng

    (Jingjie PTM BioLab Co. Ltd., Hangzhou Economic and Technological Development Area)

  • Lei Shi

    (2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University)

  • Yongfeng Shang

    (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), School of Basic Medical Sciences, Peking University Health Science Center
    2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University)

  • Wenhua Yu

    (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), School of Basic Medical Sciences, Peking University Health Science Center)

Abstract

Although SIRT7 is a member of sirtuin family proteins that are described as NAD+-dependent class III histone deacetylases, the intrinsic enzymatic activity of this sirtuin protein remains to be investigated and the cellular function of SIRT7 remains to be explored. Here we report that SIRT7 is an NAD+-dependent histone desuccinylase. We show that SIRT7 is recruited to DNA double-strand breaks (DSBs) in a PARP1-dependent manner and catalyses desuccinylation of H3K122 therein, thereby promoting chromatin condensation and DSB repair. We demonstrate that depletion of SIRT7 impairs chromatin compaction during DNA-damage response and sensitizes cells to genotoxic stresses. Our study indicates SIRT7 is a histone desuccinylase, providing a molecular basis for the understanding of epigenetic regulation by this sirtuin protein. Our experiments reveal that SIRT7-catalysed H3K122 desuccinylation is critically implemented in DNA-damage response and cell survival, providing a mechanistic insight into the cellular function of SIRT7.

Suggested Citation

  • Lei Li & Lan Shi & Shangda Yang & Ruorong Yan & Di Zhang & Jianguo Yang & Lin He & Wanjin Li & Xia Yi & Luyang Sun & Jing Liang & Zhongyi Cheng & Lei Shi & Yongfeng Shang & Wenhua Yu, 2016. "SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability," Nature Communications, Nature, vol. 7(1), pages 1-17, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12235
    DOI: 10.1038/ncomms12235
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    Cited by:

    1. Hao-Lian Wang & Yan Chen & Yun-Qian Wang & En-Wei Tao & Juan Tan & Qian-Qian Liu & Chun-Min Li & Xue-Mei Tong & Qin-Yan Gao & Jie Hong & Ying-Xuan Chen & Jing-Yuan Fang, 2022. "Sirtuin5 protects colorectal cancer from DNA damage by keeping nucleotide availability," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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