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A conserved abundant cytoplasmic long noncoding RNA modulates repression by Pumilio proteins in human cells

Author

Listed:
  • Ailone Tichon

    (Weizmann Institute of Science)

  • Noa Gil

    (Weizmann Institute of Science)

  • Yoav Lubelsky

    (Weizmann Institute of Science)

  • Tal Havkin Solomon

    (Weizmann Institute of Science)

  • Doron Lemze

    (Department of Molecular Cell Biology,Weizmann Institute of Science)

  • Shalev Itzkovitz

    (Department of Molecular Cell Biology,Weizmann Institute of Science)

  • Noam Stern-Ginossar

    (Weizmann Institute of Science)

  • Igor Ulitsky

    (Weizmann Institute of Science)

Abstract

Thousands of long noncoding RNA (lncRNA) genes are encoded in the human genome, and hundreds of them are evolutionarily conserved, but their functions and modes of action remain largely obscure. Particularly enigmatic lncRNAs are those that are exported to the cytoplasm, including NORAD—an abundant and highly conserved cytoplasmic lncRNA. Here we show that most of the sequence of NORAD is comprised of repetitive units that together contain at least 17 functional binding sites for the two mammalian Pumilio homologues. Through binding to PUM1 and PUM2, NORAD modulates the mRNA levels of their targets, which are enriched for genes involved in chromosome segregation during cell division. Our results suggest that some cytoplasmic lncRNAs function by modulating the activities of RNA-binding proteins, an activity which positions them at key junctions of cellular signalling pathways.

Suggested Citation

  • Ailone Tichon & Noa Gil & Yoav Lubelsky & Tal Havkin Solomon & Doron Lemze & Shalev Itzkovitz & Noam Stern-Ginossar & Igor Ulitsky, 2016. "A conserved abundant cytoplasmic long noncoding RNA modulates repression by Pumilio proteins in human cells," Nature Communications, Nature, vol. 7(1), pages 1-10, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12209
    DOI: 10.1038/ncomms12209
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    Cited by:

    1. Amir Argoetti & Dor Shalev & Galia Polyak & Noa Shima & Hadas Biran & Tamar Lahav & Tamar Hashimshony & Yael Mandel-Gutfreund, 2025. "lncRNA NORAD modulates STAT3/STAT1 balance and innate immune responses in human cells via interaction with STAT3," Nature Communications, Nature, vol. 16(1), pages 1-14, December.

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