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A rhesus macaque model of Asian-lineage Zika virus infection

Author

Listed:
  • Dawn M. Dudley

    (University of Wisconsin-Madison)

  • Matthew T. Aliota

    (University of Wisconsin-Madison)

  • Emma L. Mohr

    (School of Medicine and Public Health, University of Wisconsin-Madison)

  • Andrea M. Weiler

    (Wisconsin National Primate Research Center, University of Wisconsin-Madison)

  • Gabrielle Lehrer-Brey

    (Wisconsin National Primate Research Center, University of Wisconsin-Madison)

  • Kim L. Weisgrau

    (Wisconsin National Primate Research Center, University of Wisconsin-Madison)

  • Mariel S. Mohns

    (University of Wisconsin-Madison)

  • Meghan E. Breitbach

    (University of Wisconsin-Madison)

  • Mustafa N. Rasheed

    (University of Wisconsin-Madison)

  • Christina M. Newman

    (University of Wisconsin-Madison)

  • Dane D. Gellerup

    (Wisconsin National Primate Research Center, University of Wisconsin-Madison)

  • Louise H. Moncla

    (University of Wisconsin-Madison
    University of Wisconsin-Madison)

  • Jennifer Post

    (Wisconsin National Primate Research Center, University of Wisconsin-Madison)

  • Nancy Schultz-Darken

    (Wisconsin National Primate Research Center, University of Wisconsin-Madison)

  • Michele L. Schotzko

    (Wisconsin National Primate Research Center, University of Wisconsin-Madison)

  • Jennifer M. Hayes

    (Wisconsin National Primate Research Center, University of Wisconsin-Madison)

  • Josh A. Eudailey

    (Duke University Medical Center)

  • M. Anthony Moody

    (Duke University Medical Center)

  • Sallie R. Permar

    (Duke University Medical Center)

  • Shelby L. O’Connor

    (University of Wisconsin-Madison)

  • Eva G. Rakasz

    (Wisconsin National Primate Research Center, University of Wisconsin-Madison)

  • Heather A. Simmons

    (Wisconsin National Primate Research Center, University of Wisconsin-Madison)

  • Saverio Capuano

    (Wisconsin National Primate Research Center, University of Wisconsin-Madison)

  • Thaddeus G. Golos

    (Wisconsin National Primate Research Center, University of Wisconsin-Madison
    University of Wisconsin-Madison)

  • Jorge E. Osorio

    (University of Wisconsin-Madison)

  • Thomas C. Friedrich

    (University of Wisconsin-Madison
    Wisconsin National Primate Research Center, University of Wisconsin-Madison)

  • David H. O’Connor

    (University of Wisconsin-Madison
    Wisconsin National Primate Research Center, University of Wisconsin-Madison)

Abstract

Infection with Asian-lineage Zika virus (ZIKV) has been associated with Guillain–Barré syndrome and fetal abnormalities, but the underlying mechanisms remain poorly understood. Animal models of infection are thus urgently needed. Here we show that rhesus macaques are susceptible to infection by an Asian-lineage ZIKV closely related to strains currently circulating in the Americas. Following subcutaneous inoculation, ZIKV RNA is detected in plasma 1 day post infection (d.p.i.) in all animals (N=8, including 2 pregnant animals), and is also present in saliva, urine and cerebrospinal fluid. Non-pregnant and pregnant animals remain viremic for 21 days and for up to at least 57 days, respectively. Neutralizing antibodies are detected by 21 d.p.i. Rechallenge 10 weeks after the initial challenge results in no detectable virus replication, indicating protective immunity against homologous strains. Therefore, Asian-lineage ZIKV infection of rhesus macaques provides a relevant animal model for studying pathogenesis and evaluating potential interventions against human infection, including during pregnancy.

Suggested Citation

  • Dawn M. Dudley & Matthew T. Aliota & Emma L. Mohr & Andrea M. Weiler & Gabrielle Lehrer-Brey & Kim L. Weisgrau & Mariel S. Mohns & Meghan E. Breitbach & Mustafa N. Rasheed & Christina M. Newman & Dane, 2016. "A rhesus macaque model of Asian-lineage Zika virus infection," Nature Communications, Nature, vol. 7(1), pages 1-9, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12204
    DOI: 10.1038/ncomms12204
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