IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v7y2016i1d10.1038_ncomms12186.html
   My bibliography  Save this article

Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway

Author

Listed:
  • Ruani N. Fernando

    (Institut des Neurosciences de Montpellier, INSERM U1051, University of Montpellier, Hopital Saint Eloi)

  • Laurent Cotter

    (Institut des Neurosciences de Montpellier, INSERM U1051, University of Montpellier, Hopital Saint Eloi)

  • Claire Perrin-Tricaud

    (Institut des Neurosciences de Montpellier, INSERM U1051, University of Montpellier, Hopital Saint Eloi)

  • Jade Berthelot

    (Institut des Neurosciences de Montpellier, INSERM U1051, University of Montpellier, Hopital Saint Eloi)

  • Sylvain Bartolami

    (Institut des Neurosciences de Montpellier, INSERM U1051, University of Montpellier, Hopital Saint Eloi)

  • Jorge A. Pereira

    (ETH, Institute of Molecular Health Sciences)

  • Sergio Gonzalez

    (Institut des Neurosciences de Montpellier, INSERM U1051, University of Montpellier, Hopital Saint Eloi)

  • Ueli Suter

    (ETH, Institute of Molecular Health Sciences)

  • Nicolas Tricaud

    (Institut des Neurosciences de Montpellier, INSERM U1051, University of Montpellier, Hopital Saint Eloi)

Abstract

Fast nerve conduction relies on successive myelin segments that electrically isolate axons. Segment geometry—diameter and length—is critical for the optimization of nerve conduction and the molecular mechanisms allowing this optimized geometry are partially known. We show here that peripheral myelin elongation is dynamically regulated by stimulation of YAP (Yes-associated protein) transcription cofactor activity during axonal elongation and limited by inhibition of YAP activity via the Hippo pathway. YAP promotes myelin and non-myelin genes transcription while the polarity protein Crb3, localized at the tips of the myelin sheath, activates the Hippo pathway to temper YAP activity, therefore allowing for optimal myelin growth. Dystrophic Dy2j/2j mice mimicking human peripheral neuropathy with reduced internodal lengths have decreased nuclear YAP which, when corrected, leads to longer internodes. These data show a novel mechanism controlling myelin growth and nerve conduction, and provide a molecular ground for disease with short myelin segments.

Suggested Citation

  • Ruani N. Fernando & Laurent Cotter & Claire Perrin-Tricaud & Jade Berthelot & Sylvain Bartolami & Jorge A. Pereira & Sergio Gonzalez & Ueli Suter & Nicolas Tricaud, 2016. "Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway," Nature Communications, Nature, vol. 7(1), pages 1-14, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12186
    DOI: 10.1038/ncomms12186
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms12186
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms12186?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12186. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.