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αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development

Author

Listed:
  • Chun-Ying Li

    (Zhongshan Hospital of Dalian University
    University of California)

  • Jimmy Hu

    (University of California)

  • Hongbing Lu

    (University of California)

  • Jing Lan

    (University of California)

  • Wei Du

    (University of California)

  • Nicole Galicia

    (University of California)

  • Ophir D. Klein

    (University of California
    University of California)

Abstract

Embryonic signalling centres are specialized clusters of non-proliferating cells that direct the development of many organs. However, the mechanisms that establish these essential structures in mammals are not well understood. Here we report, using the murine incisor as a model, that αE-catenin is essential for inhibiting nuclear YAP localization and cell proliferation. This function of αE-catenin is required for formation of the tooth signalling centre, the enamel knot (EK), which maintains dental mesenchymal condensation and epithelial invagination. EK formation depends primarily on the signalling function of αE-catenin through YAP and its homologue TAZ, as opposed to its adhesive function, and combined deletion of Yap and Taz rescues the EK defects caused by loss of αE-catenin. These findings point to a developmental mechanism by which αE-catenin restricts YAP/TAZ activity to establish a group of non-dividing and specialized cells that constitute a signalling centre.

Suggested Citation

  • Chun-Ying Li & Jimmy Hu & Hongbing Lu & Jing Lan & Wei Du & Nicole Galicia & Ophir D. Klein, 2016. "αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development," Nature Communications, Nature, vol. 7(1), pages 1-13, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12133
    DOI: 10.1038/ncomms12133
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