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RNA polymerase I–Rrn3 complex at 4.8 Å resolution

Author

Listed:
  • Christoph Engel

    (Max Planck Institute for Biophysical Chemistry)

  • Jürgen Plitzko

    (Max Planck Institute for Biochemistry)

  • Patrick Cramer

    (Max Planck Institute for Biophysical Chemistry)

Abstract

Transcription of ribosomal DNA by RNA polymerase I (Pol I) requires the initiation factor Rrn3. Here we report the cryo-EM structure of the Pol I–Rrn3 complex at 4.8 Å resolution. The structure reveals how Rrn3 binding converts an inactive Pol I dimer into an initiation-competent monomeric complex and provides insights into the mechanisms of Pol I-specific initiation and regulation.

Suggested Citation

  • Christoph Engel & Jürgen Plitzko & Patrick Cramer, 2016. "RNA polymerase I–Rrn3 complex at 4.8 Å resolution," Nature Communications, Nature, vol. 7(1), pages 1-5, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12129
    DOI: 10.1038/ncomms12129
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