IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v7y2016i1d10.1038_ncomms12082.html
   My bibliography  Save this article

The neuritic plaque facilitates pathological conversion of tau in an Alzheimer’s disease mouse model

Author

Listed:
  • Tong Li

    (The Johns Hopkins University School of Medicine)

  • Kerstin E. Braunstein

    (The Johns Hopkins University School of Medicine)

  • Juhong Zhang

    (The Johns Hopkins University School of Medicine)

  • Ashley Lau

    (The Johns Hopkins University School of Medicine)

  • Leslie Sibener

    (The Johns Hopkins University School of Medicine)

  • Christopher Deeble

    (The Johns Hopkins University School of Medicine)

  • Philip C. Wong

    (The Johns Hopkins University School of Medicine
    The Johns Hopkins University School of Medicine)

Abstract

A central question in Alzheimer’s Disease (AD) is whether the neuritic plaque is necessary and sufficient for the development of tau pathology. Hyperphosphorylation of tau is found within dystrophic neurites surrounding β-amyloid deposits in AD mouse models but the pathological conversion of tau is absent. Likewise, expression of a human tau repeat domain in mice is insufficient to drive the pathological conversion of tau. Here we developed an Aβ-amyloidosis mouse model that expresses the human tau repeat domain and show that in these mice, the neuritic plaque facilitates the pathological conversion of wild-type tau. We show that this tau fragment seeds the neuritic plaque-dependent pathological conversion of wild-type tau that spreads from the cortex and hippocampus to the brain stem. These results establish that in addition to the neuritic plaque, a second determinant is required to drive the conversion of wild-type tau.

Suggested Citation

  • Tong Li & Kerstin E. Braunstein & Juhong Zhang & Ashley Lau & Leslie Sibener & Christopher Deeble & Philip C. Wong, 2016. "The neuritic plaque facilitates pathological conversion of tau in an Alzheimer’s disease mouse model," Nature Communications, Nature, vol. 7(1), pages 1-13, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12082
    DOI: 10.1038/ncomms12082
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms12082
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms12082?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12082. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.