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Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma

Author

Listed:
  • Harvind S. Chahal

    (Stanford University School of Medicine)

  • Yuan Lin

    (Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University)

  • Katherine J. Ransohoff

    (Stanford University School of Medicine)

  • David A. Hinds

    (23andMe Inc.)

  • Wenting Wu

    (Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University)

  • Hong-Ji Dai

    (Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University
    Tianjin Medical University Cancer Hospital and Institute, National Clinical Research Center for Cancer, Tianjin & Key Laboratory of Cancer Prevention and Therapy)

  • Abrar A. Qureshi

    (Warren Alpert Medical School, Brown University
    School of Public Health, Brown University
    Brigham and Women’s Hospital, Harvard Medical School)

  • Wen-Qing Li

    (Warren Alpert Medical School, Brown University
    School of Public Health, Brown University)

  • Peter Kraft

    (Harvard T.H. Chan School of Public Health
    Harvard T.H. Chan School of Public Health)

  • Jean Y. Tang

    (Stanford University School of Medicine)

  • Jiali Han

    (Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University
    Tianjin Medical University Cancer Hospital and Institute, National Clinical Research Center for Cancer, Tianjin & Key Laboratory of Cancer Prevention and Therapy
    Harvard T.H. Chan School of Public Health)

  • Kavita Y. Sarin

    (Stanford University School of Medicine)

Abstract

Cutaneous squamous cell carcinoma represents the second most common cutaneous malignancy, affecting 7–11% of Caucasians in the United States. The genetic determinants of susceptibility to cutaneous squamous cell carcinoma remain largely unknown. Here we report the results of a two-stage genome-wide association study of cutaneous squamous cell carcinoma, totalling 7,404 cases and 292,076 controls. Eleven loci reached genome-wide significance (P

Suggested Citation

  • Harvind S. Chahal & Yuan Lin & Katherine J. Ransohoff & David A. Hinds & Wenting Wu & Hong-Ji Dai & Abrar A. Qureshi & Wen-Qing Li & Peter Kraft & Jean Y. Tang & Jiali Han & Kavita Y. Sarin, 2016. "Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma," Nature Communications, Nature, vol. 7(1), pages 1-8, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12048
    DOI: 10.1038/ncomms12048
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    Cited by:

    1. Meghana Pagadala & Timothy J. Sears & Victoria H. Wu & Eva Pérez-Guijarro & Hyo Kim & Andrea Castro & James V. Talwar & Cristian Gonzalez-Colin & Steven Cao & Benjamin J. Schmiedel & Shervin Goudarzi , 2023. "Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    2. Mathias Seviiri & Matthew H. Law & Jue-Sheng Ong & Puya Gharahkhani & Pierre Fontanillas & Catherine M. Olsen & David C. Whiteman & Stuart MacGregor, 2022. "A multi-phenotype analysis reveals 19 susceptibility loci for basal cell carcinoma and 15 for squamous cell carcinoma," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Gianmarco Mignogna & Caitlin E. Carey & Robbee Wedow & Nikolas Baya & Mattia Cordioli & Nicola Pirastu & Rino Bellocco & Kathryn Fiuza Malerbi & Michel G. Nivard & Benjamin M. Neale & Raymond K. Walte, 2023. "Patterns of item nonresponse behaviour to survey questionnaires are systematic and associated with genetic loci," Nature Human Behaviour, Nature, vol. 7(8), pages 1371-1387, August.
    4. Beomsu Kim & Dan Say Kim & Joong-Gon Shin & Sangseob Leem & Minyoung Cho & Hanji Kim & Ki-Nam Gu & Jung Yeon Seo & Seung Won You & Alicia R. Martin & Sun Gyoo Park & Yunkwan Kim & Choongwon Jeong & Na, 2024. "Mapping and annotating genomic loci to prioritize genes and implicate distinct polygenic adaptations for skin color," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    5. James J. Gilchrist & Seiko Makino & Vivek Naranbhai & Piyush K. Sharma & Surya Koturan & Orion Tong & Chelsea A. Taylor & Robert A. Watson & Alba Verge los Aires & Rosalin Cooper & Evelyn Lau & Sara D, 2022. "Natural Killer cells demonstrate distinct eQTL and transcriptome-wide disease associations, highlighting their role in autoimmunity," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    6. Ke Mao & Christelle Borel & Muhammad Ansar & Angad Jolly & Periklis Makrythanasis & Christine Froehlich & Justyna Iwaszkiewicz & Bingqing Wang & Xiaopeng Xu & Qiang Li & Xavier Blanc & Hao Zhu & Qi Ch, 2023. "FOXI3 pathogenic variants cause one form of craniofacial microsomia," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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