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Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury

Author

Listed:
  • Jiyun Peng

    (Rutgers University)

  • Nan Gu

    (Rutgers University
    Xijing Hospital, Fourth Military Medical University)

  • Lijun Zhou

    (Rutgers University
    Zhongshan School of Medicine, Sun Yet-Sen University)

  • Ukpong B Eyo

    (Rutgers University)

  • Madhuvika Murugan

    (Rutgers University)

  • Wen-Biao Gan

    (Skirball Institute, New York University School of Medicine)

  • Long-Jun Wu

    (Rutgers University)

Abstract

Microglia and peripheral monocytes contribute to hypersensitivity in rodent models of neuropathic pain. However, the precise respective function of microglia and peripheral monocytes has not been investigated in these models. To address this question, here we combined transgenic mice and pharmacological tools to specifically and temporally control the depletion of microglia and monocytes in a mouse model of spinal nerve transection (SNT). We found that although microglia and monocytes are required during the initiation of mechanical allodynia or thermal hyperalgesia, these cells may not be as important for the maintenance of hypersensitivity. Moreover, we demonstrated that either resident microglia or peripheral monocytes are sufficient in gating neuropathic pain after SNT. We propose that resident microglia and peripheral monocytes act synergistically to initiate hypersensitivity and promote the transition from acute to chronic pain after peripheral nerve injury.

Suggested Citation

  • Jiyun Peng & Nan Gu & Lijun Zhou & Ukpong B Eyo & Madhuvika Murugan & Wen-Biao Gan & Long-Jun Wu, 2016. "Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury," Nature Communications, Nature, vol. 7(1), pages 1-13, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12029
    DOI: 10.1038/ncomms12029
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    Cited by:

    1. Jiyun Peng & Qian Zou & Min-Jie Chen & Chao-Lin Ma & Bao-Ming Li, 2022. "Motor deficits seen in microglial ablation mice could be due to non-specific damage from high dose diphtheria toxin treatment," Nature Communications, Nature, vol. 13(1), pages 1-4, December.
    2. Lauren A Green & Julia C Nebiolo & Cody J Smith, 2019. "Microglia exit the CNS in spinal root avulsion," PLOS Biology, Public Library of Science, vol. 17(2), pages 1-30, February.

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