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Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration

Author

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  • C. Colin Brinkman

    (Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
    University of Maryland School of Medicine
    University of Maryland School of Medicine)

  • Daiki Iwami

    (Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
    University of Maryland School of Medicine
    Present address: Department of Renal and Genito-Urinary Surgery, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, Japan.)

  • Molly K. Hritzo

    (University of Maryland School of Medicine)

  • Yanbao Xiong

    (Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
    University of Maryland School of Medicine
    University of Maryland School of Medicine)

  • Sarwat Ahmad

    (Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
    University of Maryland School of Medicine)

  • Thomas Simon

    (Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
    University of Maryland School of Medicine
    University of Maryland School of Medicine)

  • Keli L. Hippen

    (University of Minnesota Cancer Center)

  • Bruce R. Blazar

    (University of Minnesota Cancer Center)

  • Jonathan S. Bromberg

    (Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
    University of Maryland School of Medicine
    University of Maryland School of Medicine)

Abstract

Regulatory T cells (Tregs) are essential to suppress unwanted immunity or inflammation. After islet allo-transplant Tregs must migrate from blood to allograft, then via afferent lymphatics to draining LN to protect allografts. Here we show that Tregs but not non-Treg T cells use lymphotoxin (LT) during migration from allograft to draining LN, and that LT deficiency or blockade prevents normal migration and allograft protection. Treg LTαβ rapidly modulates cytoskeletal and membrane structure of lymphatic endothelial cells; dependent on VCAM-1 and non-canonical NFκB signalling via LTβR. These results demonstrate a form of T-cell migration used only by Treg in tissues that serves an important role in their suppressive function and is a unique therapeutic focus for modulating suppression.

Suggested Citation

  • C. Colin Brinkman & Daiki Iwami & Molly K. Hritzo & Yanbao Xiong & Sarwat Ahmad & Thomas Simon & Keli L. Hippen & Bruce R. Blazar & Jonathan S. Bromberg, 2016. "Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration," Nature Communications, Nature, vol. 7(1), pages 1-16, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12021
    DOI: 10.1038/ncomms12021
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    Cited by:

    1. Wenji Piao & Lushen Li & Vikas Saxena & Jegan Iyyathurai & Ram Lakhan & Yigang Zhang & Isadora Tadeval Lape & Christina Paluskievicz & Keli L. Hippen & Young Lee & Emma Silverman & Marina W. Shirkey &, 2022. "PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Alexia Borelli & Jérémy C. Santamaria & Cloé Zamit & Cécile Apert & Jessica Chevallier & Philippe Pierre & Rafael J. Argüello & Lionel Spinelli & Magali Irla, 2024. "Lymphotoxin limits Foxp3+ regulatory T cell development from Foxp3lo precursors via IL-4 signaling," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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