IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v7y2016i1d10.1038_ncomms12021.html
   My bibliography  Save this article

Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration

Author

Listed:
  • C. Colin Brinkman

    (Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
    University of Maryland School of Medicine
    University of Maryland School of Medicine)

  • Daiki Iwami

    (Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
    University of Maryland School of Medicine
    Present address: Department of Renal and Genito-Urinary Surgery, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, Japan.)

  • Molly K. Hritzo

    (University of Maryland School of Medicine)

  • Yanbao Xiong

    (Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
    University of Maryland School of Medicine
    University of Maryland School of Medicine)

  • Sarwat Ahmad

    (Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
    University of Maryland School of Medicine)

  • Thomas Simon

    (Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
    University of Maryland School of Medicine
    University of Maryland School of Medicine)

  • Keli L. Hippen

    (University of Minnesota Cancer Center)

  • Bruce R. Blazar

    (University of Minnesota Cancer Center)

  • Jonathan S. Bromberg

    (Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
    University of Maryland School of Medicine
    University of Maryland School of Medicine)

Abstract

Regulatory T cells (Tregs) are essential to suppress unwanted immunity or inflammation. After islet allo-transplant Tregs must migrate from blood to allograft, then via afferent lymphatics to draining LN to protect allografts. Here we show that Tregs but not non-Treg T cells use lymphotoxin (LT) during migration from allograft to draining LN, and that LT deficiency or blockade prevents normal migration and allograft protection. Treg LTαβ rapidly modulates cytoskeletal and membrane structure of lymphatic endothelial cells; dependent on VCAM-1 and non-canonical NFκB signalling via LTβR. These results demonstrate a form of T-cell migration used only by Treg in tissues that serves an important role in their suppressive function and is a unique therapeutic focus for modulating suppression.

Suggested Citation

  • C. Colin Brinkman & Daiki Iwami & Molly K. Hritzo & Yanbao Xiong & Sarwat Ahmad & Thomas Simon & Keli L. Hippen & Bruce R. Blazar & Jonathan S. Bromberg, 2016. "Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration," Nature Communications, Nature, vol. 7(1), pages 1-16, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12021
    DOI: 10.1038/ncomms12021
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms12021
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms12021?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Wenji Piao & Lushen Li & Vikas Saxena & Jegan Iyyathurai & Ram Lakhan & Yigang Zhang & Isadora Tadeval Lape & Christina Paluskievicz & Keli L. Hippen & Young Lee & Emma Silverman & Marina W. Shirkey &, 2022. "PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12021. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.