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Alterations of the human gut microbiome in multiple sclerosis

Author

Listed:
  • Sushrut Jangi

    (Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School)

  • Roopali Gandhi

    (Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School)

  • Laura M. Cox

    (Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School)

  • Ning Li

    (Center for Clinical and Translational Metagenomics, Brigham and Women's Hospital, Harvard Medical School)

  • Felipe von Glehn

    (Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School)

  • Raymond Yan

    (Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School)

  • Bonny Patel

    (Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School)

  • Maria Antonietta Mazzola

    (Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School)

  • Shirong Liu

    (Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School)

  • Bonnie L. Glanz

    (Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School)

  • Sandra Cook

    (Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School)

  • Stephanie Tankou

    (Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School)

  • Fiona Stuart

    (Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School)

  • Kirsy Melo

    (Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School)

  • Parham Nejad

    (Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School)

  • Kathleen Smith

    (Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School)

  • Begüm D. Topçuolu

    (University of Massachusetts)

  • James Holden

    (University of Massachusetts)

  • Pia Kivisäkk

    (Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School)

  • Tanuja Chitnis

    (Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School)

  • Philip L. De Jager

    (Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School)

  • Francisco J. Quintana

    (Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School)

  • Georg K. Gerber

    (Center for Clinical and Translational Metagenomics, Brigham and Women's Hospital, Harvard Medical School)

  • Lynn Bry

    (Center for Clinical and Translational Metagenomics, Brigham and Women's Hospital, Harvard Medical School)

  • Howard L. Weiner

    (Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School)

Abstract

The gut microbiome plays an important role in immune function and has been implicated in several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the gut microbiome in subjects with multiple sclerosis (MS, n=60) and healthy controls (n=43). Microbiome alterations in MS include increases in Methanobrevibacter and Akkermansia and decreases in Butyricimonas, and correlate with variations in the expression of genes involved in dendritic cell maturation, interferon signalling and NF-kB signalling pathways in circulating T cells and monocytes. Patients on disease-modifying treatment show increased abundances of Prevotella and Sutterella, and decreased Sarcina, compared with untreated patients. MS patients of a second cohort show elevated breath methane compared with controls, consistent with our observation of increased gut Methanobrevibacter in MS in the first cohort. Further study is required to assess whether the observed alterations in the gut microbiome play a role in, or are a consequence of, MS pathogenesis.

Suggested Citation

  • Sushrut Jangi & Roopali Gandhi & Laura M. Cox & Ning Li & Felipe von Glehn & Raymond Yan & Bonny Patel & Maria Antonietta Mazzola & Shirong Liu & Bonnie L. Glanz & Sandra Cook & Stephanie Tankou & Fio, 2016. "Alterations of the human gut microbiome in multiple sclerosis," Nature Communications, Nature, vol. 7(1), pages 1-11, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12015
    DOI: 10.1038/ncomms12015
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    Cited by:

    1. Caroline Wasén & Leah C. Beauchamp & Julia Vincentini & Shuqi Li & Danielle S. LeServe & Christian Gauthier & Juliana R. Lopes & Thais G. Moreira & Millicent N. Ekwudo & Zhuoran Yin & Patrick da Silva, 2024. "Bacteroidota inhibit microglia clearance of amyloid-beta and promote plaque deposition in Alzheimer’s disease mouse models," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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