IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v7y2016i1d10.1038_ncomms11939.html
   My bibliography  Save this article

A key genetic factor for fucosyllactose utilization affects infant gut microbiota development

Author

Listed:
  • Takahiro Matsuki

    (Yakult Central Institute)

  • Kana Yahagi

    (Yakult Central Institute)

  • Hiroshi Mori

    (Tokyo Institute of Technology)

  • Hoshitaka Matsumoto

    (Yakult Central Institute)

  • Taeko Hara

    (Yakult Central Institute)

  • Saya Tajima

    (Yakult Central Institute)

  • Eishin Ogawa

    (Teikyo University School of Medicine)

  • Hiroko Kodama

    (Teikyo University School of Medicine)

  • Kazuya Yamamoto

    (Tokyo Institute of Technology)

  • Takuji Yamada

    (Tokyo Institute of Technology)

  • Satoshi Matsumoto

    (Yakult Central Institute)

  • Ken Kurokawa

    (Tokyo Institute of Technology
    Earth-Life Science Institute, Tokyo Institute of Technology
    National Institute of Genetics, Center for Information Biology)

Abstract

Recent studies have demonstrated that gut microbiota development influences infants’ health and subsequent host physiology. However, the factors shaping the development of the microbiota remain poorly understood, and the mechanisms through which these factors affect gut metabolite profiles have not been extensively investigated. Here we analyse gut microbiota development of 27 infants during the first month of life. We find three distinct clusters that transition towards Bifidobacteriaceae-dominant microbiota. We observe considerable differences in human milk oligosaccharide utilization among infant bifidobacteria. Colonization of fucosyllactose (FL)-utilizing bifidobacteria is associated with altered metabolite profiles and microbiota compositions, which have been previously shown to affect infant health. Genome analysis of infants’ bifidobacteria reveals an ABC transporter as a key genetic factor for FL utilization. Thus, the ability of bifidobacteria to utilize FL and the presence of FL in breast milk may affect the development of the gut microbiota in infants, and might ultimately have therapeutic implications.

Suggested Citation

  • Takahiro Matsuki & Kana Yahagi & Hiroshi Mori & Hoshitaka Matsumoto & Taeko Hara & Saya Tajima & Eishin Ogawa & Hiroko Kodama & Kazuya Yamamoto & Takuji Yamada & Satoshi Matsumoto & Ken Kurokawa, 2016. "A key genetic factor for fucosyllactose utilization affects infant gut microbiota development," Nature Communications, Nature, vol. 7(1), pages 1-12, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11939
    DOI: 10.1038/ncomms11939
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms11939
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms11939?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yue Clare Lou & Benjamin E. Rubin & Marie C. Schoelmerich & Kaden S. DiMarco & Adair L. Borges & Rachel Rovinsky & Leo Song & Jennifer A. Doudna & Jillian F. Banfield, 2023. "Infant microbiome cultivation and metagenomic analysis reveal Bifidobacterium 2’-fucosyllactose utilization can be facilitated by coexisting species," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Raphael Watt & Kimberley Parkin & David Martino, 2020. "The Potential Effects of Short-Chain Fatty Acids on the Epigenetic Regulation of Innate Immune Memory," Challenges, MDPI, vol. 11(2), pages 1-16, October.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11939. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.