IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v7y2016i1d10.1038_ncomms11934.html
   My bibliography  Save this article

Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

Author

Listed:
  • Y. Iturria-Medina

    (McConnell Brain Imaging Centre, Montreal Neurological Institute
    Ludmer Centre for NeuroInformatics and Mental Health)

  • R. C. Sotero

    (University of Calgary)

  • P. J. Toussaint

    (McConnell Brain Imaging Centre, Montreal Neurological Institute
    Ludmer Centre for NeuroInformatics and Mental Health)

  • J. M. Mateos-Pérez

    (McConnell Brain Imaging Centre, Montreal Neurological Institute
    Ludmer Centre for NeuroInformatics and Mental Health)

  • A. C. Evans

    (McConnell Brain Imaging Centre, Montreal Neurological Institute
    Ludmer Centre for NeuroInformatics and Mental Health)

Abstract

Multifactorial mechanisms underlying late-onset Alzheimer’s disease (LOAD) are poorly characterized from an integrative perspective. Here spatiotemporal alterations in brain amyloid-β deposition, metabolism, vascular, functional activity at rest, structural properties, cognitive integrity and peripheral proteins levels are characterized in relation to LOAD progression. We analyse over 7,700 brain images and tens of plasma and cerebrospinal fluid biomarkers from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Through a multifactorial data-driven analysis, we obtain dynamic LOAD–abnormality indices for all biomarkers, and a tentative temporal ordering of disease progression. Imaging results suggest that intra-brain vascular dysregulation is an early pathological event during disease development. Cognitive decline is noticeable from initial LOAD stages, suggesting early memory deficit associated with the primary disease factors. High abnormality levels are also observed for specific proteins associated with the vascular system’s integrity. Although still subjected to the sensitivity of the algorithms and biomarkers employed, our results might contribute to the development of preventive therapeutic interventions.

Suggested Citation

  • Y. Iturria-Medina & R. C. Sotero & P. J. Toussaint & J. M. Mateos-Pérez & A. C. Evans, 2016. "Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis," Nature Communications, Nature, vol. 7(1), pages 1-14, September.
  • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11934
    DOI: 10.1038/ncomms11934
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms11934
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/ncomms11934?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Lazaro M Sanchez-Rodriguez & Yasser Iturria-Medina & Erica A Baines & Sabela C Mallo & Mehdy Dousty & Roberto C Sotero & on behalf of The Alzheimer’s Disease Neuroimaging Initiative, 2018. "Design of optimal nonlinear network controllers for Alzheimer's disease," PLOS Computational Biology, Public Library of Science, vol. 14(5), pages 1-24, May.
    2. Fotios Koskeridis & Nurun Fancy & Pei Fang Tan & Devendra Meena & Evangelos Evangelou & Paul Elliott & Dennis Wang & Paul M. Matthews & Abbas Dehghan & Ioanna Tzoulaki, 2024. "Multi-trait association analysis reveals shared genetic loci between Alzheimer’s disease and cardiovascular traits," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    3. Ahmed Faraz Khan & Quadri Adewale & Sue-Jin Lin & Tobias R. Baumeister & Yashar Zeighami & Felix Carbonell & Nicola Palomero-Gallagher & Yasser Iturria-Medina, 2023. "Patient-specific models link neurotransmitter receptor mechanisms with motor and visuospatial axes of Parkinson’s disease," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Stacy A. Hussong & Andy Q. Banh & Candice E. Skike & Angela O. Dorigatti & Stephen F. Hernandez & Matthew J. Hart & Beatriz Ferran & Haneen Makhlouf & Maria Gaczynska & Pawel A. Osmulski & Salome A. M, 2023. "Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Patrick S. Hosford & Jack A. Wells & Shereen Nizari & Isabel N. Christie & Shefeeq M. Theparambil & Pablo A. Castro & Anna Hadjihambi & L. Felipe Barros & Iván Ruminot & Mark F. Lythgoe & Alexander V., 2022. "CO2 signaling mediates neurovascular coupling in the cerebral cortex," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11934. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.