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KRT14 marks a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis

Author

Listed:
  • George Papafotiou

    (Center for Basic Research, Biomedical Research Foundation of the Academy of Athens)

  • Varvara Paraskevopoulou

    (Center for Basic Research, Biomedical Research Foundation of the Academy of Athens)

  • Eleni Vasilaki

    (Center for Basic Research, Biomedical Research Foundation of the Academy of Athens)

  • Zoi Kanaki

    (Center for Basic Research, Biomedical Research Foundation of the Academy of Athens)

  • Nikolaos Paschalidis

    (Laboratory of Cellular Immunology, Center for Basic Research, Biomedical Research Foundation of the Academy of Athens)

  • Apostolos Klinakis

    (Center for Basic Research, Biomedical Research Foundation of the Academy of Athens)

Abstract

The urothelium is a specialized epithelium that lines the urinary tract. It consists of three different cell types, namely, basal, intermediate and superficial cells arranged in relatively distinct cell layers. Normally, quiescent, it regenerates fast upon injury, but the regeneration process is not fully understood. Although several reports have indicated the existence of progenitors, their identity and exact topology, as well as their role in key processes such as tissue regeneration and carcinogenesis have not been clarified. Here we show that a minor subpopulation of basal cells, characterized by the expression of keratin 14, possesses self-renewal capacity and also gives rise to all cell types of the urothelium during natural and injury-induced regeneration. Moreover, these cells represent cells of origin of urothelial cancer. Our findings support the hypothesis of basally located progenitors with profound roles in urothelial homoeostasis.

Suggested Citation

  • George Papafotiou & Varvara Paraskevopoulou & Eleni Vasilaki & Zoi Kanaki & Nikolaos Paschalidis & Apostolos Klinakis, 2016. "KRT14 marks a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis," Nature Communications, Nature, vol. 7(1), pages 1-11, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11914
    DOI: 10.1038/ncomms11914
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    Cited by:

    1. Ayushi Verma & Akhilesh Singh & Manish Pratap Singh & Mushtaq Ahmad Nengroo & Krishan Kumar Saini & Saumya Ranjan Satrusal & Muqtada Ali Khan & Priyank Chaturvedi & Abhipsa Sinha & Sanjeev Meena & Anu, 2022. "EZH2-H3K27me3 mediated KRT14 upregulation promotes TNBC peritoneal metastasis," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    2. Tiffany Tate & Tina Xiang & Sarah E. Wobker & Mi Zhou & Xiao Chen & Hyunwoo Kim & Ekatherina Batourina & Chyuan-Sheng Lin & William Y. Kim & Chao Lu & James M. Mckiernan & Cathy Lee Mendelsohn, 2021. "Pparg signaling controls bladder cancer subtype and immune exclusion," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    3. Sakina A. Plumber & Tiffany Tate & Hikmat Al-Ahmadie & Xiao Chen & Woonyoung Choi & Merve Basar & Chao Lu & Aaron Viny & Ekatherina Batourina & Jiaqi Li & Kristjan Gretarsson & Besmira Alija & Andrei , 2024. "Rosiglitazone and trametinib exhibit potent anti-tumor activity in a mouse model of muscle invasive bladder cancer," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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