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Genetically and functionally defined NTS to PBN brain circuits mediating anorexia

Author

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  • Carolyn W. Roman

    (University of Washington)

  • Victor A. Derkach

    (University of Washington
    Howard Hughes Medical Institute, University of Washington)

  • Richard D. Palmiter

    (University of Washington
    Howard Hughes Medical Institute, University of Washington)

Abstract

The central nervous system controls food consumption to maintain metabolic homoeostasis. In response to a meal, visceral signals from the gut activate neurons in the nucleus of the solitary tract (NTS) via the vagus nerve. These NTS neurons then excite brain regions known to mediate feeding behaviour, such as the lateral parabrachial nucleus (PBN). We previously described a neural circuit for appetite suppression involving calcitonin gene-related protein (CGRP)-expressing PBN (CGRPPBN) neurons; however, the molecular identity of the inputs to these neurons was not established. Here we identify cholecystokinin (CCK) and noradrenergic, dopamine β-hydroxylase (DBH)-expressing NTS neurons as two separate populations that directly excite CGRPPBN neurons. When these NTS neurons are activated using optogenetic or chemogenetic methods, food intake decreases and with chronic stimulation mice lose body weight. Our optogenetic results reveal that CCK and DBH neurons in the NTS directly engage CGRPPBN neurons to promote anorexia.

Suggested Citation

  • Carolyn W. Roman & Victor A. Derkach & Richard D. Palmiter, 2016. "Genetically and functionally defined NTS to PBN brain circuits mediating anorexia," Nature Communications, Nature, vol. 7(1), pages 1-11, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11905
    DOI: 10.1038/ncomms11905
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    Cited by:

    1. Nilufer Sayar-Atasoy & Connor Laule & Iltan Aklan & Hyojin Kim & Yavuz Yavuz & Tayfun Ates & Ilknur Coban & Fulya Koksalar-Alkan & Jacob Rysted & Debbie Davis & Uday Singh & Muhammed Ikbal Alp & Bayra, 2023. "Adrenergic modulation of melanocortin pathway by hunger signals," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Sekun Park & Anqi Zhu & Feng Cao & Richard D. Palmiter, 2024. "Parabrachial Calca neurons mediate second-order conditioning," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    3. Joseph W. Arthurs & Anna J. Bowen & Richard D. Palmiter & Nathan A. Baertsch, 2023. "Parabrachial tachykinin1-expressing neurons involved in state-dependent breathing control," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Qingtao Sun & Daniëlle Lisdonk & Miriam Ferrer & Bruno Gegenhuber & Melody Wu & Youngkyu Park & David A. Tuveson & Jessica Tollkuhn & Tobias Janowitz & Bo Li, 2024. "Area postrema neurons mediate interleukin-6 function in cancer cachexia," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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