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Faster embryonic segmentation through elevated Delta-Notch signalling

Author

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  • Bo-Kai Liao

    (Max Planck Institute of Molecular Cell Biology and Genetics
    Francis Crick Institute, Mill Hill Laboratory)

  • David J. Jörg

    (Max Planck Institute for the Physics of Complex Systems
    Present address: Cavendish Laboratory, Department of Physics, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, UK
    Present address: The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK)

  • Andrew C. Oates

    (Max Planck Institute of Molecular Cell Biology and Genetics
    Francis Crick Institute, Mill Hill Laboratory
    University College London)

Abstract

An important step in understanding biological rhythms is the control of period. A multicellular, rhythmic patterning system termed the segmentation clock is thought to govern the sequential production of the vertebrate embryo’s body segments, the somites. Several genetic loss-of-function conditions, including the Delta-Notch intercellular signalling mutants, result in slower segmentation. Here, we generate DeltaD transgenic zebrafish lines with a range of copy numbers and correspondingly increased signalling levels, and observe faster segmentation. The highest-expressing line shows an altered oscillating gene expression wave pattern and shortened segmentation period, producing embryos with more, shorter body segments. Our results reveal surprising differences in how Notch signalling strength is quantitatively interpreted in different organ systems, and suggest a role for intercellular communication in regulating the output period of the segmentation clock by altering its spatial pattern.

Suggested Citation

  • Bo-Kai Liao & David J. Jörg & Andrew C. Oates, 2016. "Faster embryonic segmentation through elevated Delta-Notch signalling," Nature Communications, Nature, vol. 7(1), pages 1-12, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11861
    DOI: 10.1038/ncomms11861
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