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Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD

Author

Listed:
  • Wei Lin

    (State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences)

  • Jing Zhang

    (State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences)

  • Haiyan Lin

    (State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences)

  • Zexing Li

    (State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences)

  • Xiaofeng Sun

    (State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences)

  • Di Xin

    (State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences)

  • Meng Yang

    (State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences)

  • Liwei Sun

    (State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences)

  • Lin Li

    (State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences)

  • Hongmei Wang

    (State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences)

  • Dahua Chen

    (State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences)

  • Qinmiao Sun

    (State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences)

Abstract

Retinoic acid-inducible gene I (RIG-I) plays important roles in pathogen recognition and antiviral signalling transduction. Here we show that syndecan-4 (SDC4) is a RIG-I-interacting partner identified in a yeast two-hybrid screen. We find that SDC4 negatively regulates the RIG-I-mediated antiviral signalling in a feedback-loop control manner. The genetic evidence obtained by using knockout mice further emphasizes this biological role of SDC4 in antiviral signalling. Mechanistically, we show that SDC4 interacts with both RIG-I and deubiquitinase CYLD via its carboxyl-terminal intracellular region. SDC4 likely promotes redistribution of RIG-I and CYLD in a perinuclear pattern post viral infection, and thus enhances the RIG-I–CYLD interaction and potentiates the K63-linked deubiquitination of RIG-I. Collectively, our findings uncover a mechanism by which SDC4 antagonizes the activation of RIG-I in a CYLD-mediated deubiquitination-dependent process, thereby balancing antiviral signalling to avoid deleterious effects on host cells.

Suggested Citation

  • Wei Lin & Jing Zhang & Haiyan Lin & Zexing Li & Xiaofeng Sun & Di Xin & Meng Yang & Liwei Sun & Lin Li & Hongmei Wang & Dahua Chen & Qinmiao Sun, 2016. "Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD," Nature Communications, Nature, vol. 7(1), pages 1-15, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11848
    DOI: 10.1038/ncomms11848
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    Cited by:

    1. Indranil Paul & Dante Bolzan & Ahmed Youssef & Keith A. Gagnon & Heather Hook & Gopal Karemore & Michael U. J. Oliphant & Weiwei Lin & Qian Liu & Sadhna Phanse & Carl White & Dzmitry Padhorny & Sergei, 2023. "Parallelized multidimensional analytic framework applied to mammary epithelial cells uncovers regulatory principles in EMT," Nature Communications, Nature, vol. 14(1), pages 1-23, December.

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