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A restricted period for formation of outer subventricular zone defined by Cdh1 and Trnp1 levels

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  • Maria Ángeles Martínez-Martínez

    (Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández)

  • Camino De Juan Romero

    (Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández)

  • Virginia Fernández

    (Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández)

  • Adrián Cárdenas

    (Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández)

  • Magdalena Götz

    (Helmholtz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research
    Physiological Genomics, University of Munich
    SYNERGY, Excellence Cluster of Systems, Neurology, Biomedical Center)

  • Víctor Borrell

    (Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández)

Abstract

The outer subventricular zone (OSVZ) is a germinal layer playing key roles in the development of the neocortex, with particular relevance in gyrencephalic species such as human and ferret, where it contains abundant basal radial glia cells (bRGCs) that promote cortical expansion. Here we identify a brief period in ferret embryonic development when apical RGCs generate a burst of bRGCs that become founders of the OSVZ. After this period, bRGCs in the OSVZ proliferate and self-renew exclusively locally, thereby forming a self-sustained lineage independent from the other germinal layers. The time window for the brief period of OSVZ bRGC production is delineated by the coincident downregulation of Cdh1 and Trnp1, and their upregulation reduces bRGC production and prevents OSVZ seeding. This mechanism in cortical development may have key relevance in brain evolution and disease.

Suggested Citation

  • Maria Ángeles Martínez-Martínez & Camino De Juan Romero & Virginia Fernández & Adrián Cárdenas & Magdalena Götz & Víctor Borrell, 2016. "A restricted period for formation of outer subventricular zone defined by Cdh1 and Trnp1 levels," Nature Communications, Nature, vol. 7(1), pages 1-15, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11812
    DOI: 10.1038/ncomms11812
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