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Store-independent modulation of Ca2+ entry through Orai by Septin 7

Author

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  • Bipan Kumar Deb

    (National Centre for Biological Sciences, Tata Institute of Fundamental Research)

  • Trayambak Pathak

    (National Centre for Biological Sciences, Tata Institute of Fundamental Research
    Manipal University)

  • Gaiti Hasan

    (National Centre for Biological Sciences, Tata Institute of Fundamental Research)

Abstract

Orai channels are required for store-operated Ca2+ entry (SOCE) in multiple cell types. Septins are a class of GTP-binding proteins that function as diffusion barriers in cells. Here we show that Septin 7 acts as a ‘molecular brake’ on activation of Orai channels in Drosophila neurons. Lowering Septin 7 levels results in dOrai-mediated Ca2+ entry and higher cytosolic Ca2+ in resting neurons. This Ca2+ entry is independent of depletion of endoplasmic reticulum Ca2+ stores and Ca2+ release through the inositol-1,4,5-trisphosphate receptor. Importantly, store-independent Ca2+ entry through Orai compensates for reduced SOCE in the Drosophila flight circuit. Moreover, overexpression of Septin 7 reduces both SOCE and flight duration, supporting its role as a negative regulator of Orai channel function in vivo. Septin 7 levels in neurons can, therefore, alter neural circuit function by modulating Orai function and Ca2+ homeostasis.

Suggested Citation

  • Bipan Kumar Deb & Trayambak Pathak & Gaiti Hasan, 2016. "Store-independent modulation of Ca2+ entry through Orai by Septin 7," Nature Communications, Nature, vol. 7(1), pages 1-15, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11751
    DOI: 10.1038/ncomms11751
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