IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v7y2016i1d10.1038_ncomms11634.html
   My bibliography  Save this article

Vascular control of the Drosophila haematopoietic microenvironment by Slit/Robo signalling

Author

Listed:
  • Ismaël Morin-Poulard

    (Centre de Biologie du Développement, UMR 5547 CNRS/Université Toulouse III and Fédération de Recherche de Biologie de Toulouse
    Present address: Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands)

  • Anurag Sharma

    (Centre de Biologie du Développement, UMR 5547 CNRS/Université Toulouse III and Fédération de Recherche de Biologie de Toulouse)

  • Isabelle Louradour

    (Centre de Biologie du Développement, UMR 5547 CNRS/Université Toulouse III and Fédération de Recherche de Biologie de Toulouse)

  • Nathalie Vanzo

    (Centre de Biologie du Développement, UMR 5547 CNRS/Université Toulouse III and Fédération de Recherche de Biologie de Toulouse)

  • Alain Vincent

    (Centre de Biologie du Développement, UMR 5547 CNRS/Université Toulouse III and Fédération de Recherche de Biologie de Toulouse)

  • Michèle Crozatier

    (Centre de Biologie du Développement, UMR 5547 CNRS/Université Toulouse III and Fédération de Recherche de Biologie de Toulouse)

Abstract

Self-renewal and differentiation of mammalian haematopoietic stem cells (HSCs) are controlled by a specialized microenvironment called ‘the niche’. In the bone marrow, HSCs receive signals from both the endosteal and vascular niches. The posterior signalling centre (PSC) of the larval Drosophila haematopoietic organ, the lymph gland, regulates blood cell differentiation under normal conditions and also plays a key role in controlling haematopoiesis under immune challenge. Here we report that the Drosophila vascular system also contributes to the lymph gland homoeostasis. Vascular cells produce Slit that activates Robo receptors in the PSC. Robo activation controls proliferation and clustering of PSC cells by regulating Myc, and small GTPase and DE-cadherin activity, respectively. These findings reveal that signals from the vascular system contribute to regulating the rate of blood cell differentiation via the regulation of PSC morphology.

Suggested Citation

  • Ismaël Morin-Poulard & Anurag Sharma & Isabelle Louradour & Nathalie Vanzo & Alain Vincent & Michèle Crozatier, 2016. "Vascular control of the Drosophila haematopoietic microenvironment by Slit/Robo signalling," Nature Communications, Nature, vol. 7(1), pages 1-12, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11634
    DOI: 10.1038/ncomms11634
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms11634
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms11634?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11634. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.