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A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation

Author

Listed:
  • Kaustubh Adhikari

    (Evolution and Environment, UCL Genetics Institute, University College London)

  • Macarena Fuentes-Guajardo

    (Evolution and Environment, UCL Genetics Institute, University College London
    Facultad de Ciencias de la Salud, Universidad de Tarapacá)

  • Mirsha Quinto-Sánchez

    (Centro Nacional Patagónico, CONICET, Unidad de Diversidad, Sistematica y Evolucion)

  • Javier Mendoza-Revilla

    (Evolution and Environment, UCL Genetics Institute, University College London
    Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia)

  • Juan Camilo Chacón-Duque

    (Evolution and Environment, UCL Genetics Institute, University College London)

  • Victor Acuña-Alonzo

    (Evolution and Environment, UCL Genetics Institute, University College London
    Laboratorio de Genética Molecular, Escuela Nacional de Antropologia e Historia)

  • Claudia Jaramillo

    (GENMOL (Genética Molecular), Universidad de Antioquia)

  • William Arias

    (GENMOL (Genética Molecular), Universidad de Antioquia)

  • Rodrigo Barquera Lozano

    (Laboratorio de Genética Molecular, Escuela Nacional de Antropologia e Historia
    Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM-Instituto Nacional de Medicina Genómica)

  • Gastón Macín Pérez

    (Laboratorio de Genética Molecular, Escuela Nacional de Antropologia e Historia
    Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM-Instituto Nacional de Medicina Genómica)

  • Jorge Gómez-Valdés

    (Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM))

  • Hugo Villamil-Ramírez

    (Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM-Instituto Nacional de Medicina Genómica)

  • Tábita Hunemeier

    (Universidade Federal do Rio Grande do Sul
    Present address: Departamento de Genética e Biologia Evolutiva, Universidade de São Paulo, São Paulo 05508-090, Brasil)

  • Virginia Ramallo

    (Centro Nacional Patagónico, CONICET, Unidad de Diversidad, Sistematica y Evolucion
    Universidade Federal do Rio Grande do Sul)

  • Caio C. Silva de Cerqueira

    (Centro Nacional Patagónico, CONICET, Unidad de Diversidad, Sistematica y Evolucion
    Universidade Federal do Rio Grande do Sul)

  • Malena Hurtado

    (Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia)

  • Valeria Villegas

    (Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia)

  • Vanessa Granja

    (Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia)

  • Carla Gallo

    (Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia)

  • Giovanni Poletti

    (Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia)

  • Lavinia Schuler-Faccini

    (Universidade Federal do Rio Grande do Sul)

  • Francisco M. Salzano

    (Universidade Federal do Rio Grande do Sul)

  • Maria- Cátira Bortolini

    (Universidade Federal do Rio Grande do Sul)

  • Samuel Canizales-Quinteros

    (Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM-Instituto Nacional de Medicina Genómica)

  • Michael Cheeseman

    (The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh)

  • Javier Rosique

    (Universidad de Antioquia)

  • Gabriel Bedoya

    (GENMOL (Genética Molecular), Universidad de Antioquia)

  • Francisco Rothhammer

    (Instituto de Alta Investigación, Universidad de Tarapacá)

  • Denis Headon

    (The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh)

  • Rolando González-José

    (Centro Nacional Patagónico, CONICET, Unidad de Diversidad, Sistematica y Evolucion)

  • David Balding

    (Evolution and Environment, UCL Genetics Institute, University College London
    Schools of BioSciences and Mathematics and Statistics, University of Melbourne)

  • Andrés Ruiz-Linares

    (Evolution and Environment, UCL Genetics Institute, University College London)

Abstract

We report a genome-wide association scan for facial features in ∼6,000 Latin Americans. We evaluated 14 traits on an ordinal scale and found significant association (P values

Suggested Citation

  • Kaustubh Adhikari & Macarena Fuentes-Guajardo & Mirsha Quinto-Sánchez & Javier Mendoza-Revilla & Juan Camilo Chacón-Duque & Victor Acuña-Alonzo & Claudia Jaramillo & William Arias & Rodrigo Barquera L, 2016. "A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation," Nature Communications, Nature, vol. 7(1), pages 1-11, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11616
    DOI: 10.1038/ncomms11616
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    Cited by:

    1. Tara N. Yankee & Sungryong Oh & Emma Wentworth Winchester & Andrea Wilderman & Kelsey Robinson & Tia Gordon & Jill A. Rosenfeld & Jennifer VanOudenhove & Daryl A. Scott & Elizabeth J. Leslie & Justin , 2023. "Integrative analysis of transcriptome dynamics during human craniofacial development identifies candidate disease genes," Nature Communications, Nature, vol. 14(1), pages 1-23, December.
    2. Ziyi Xiong & Xingjian Gao & Yan Chen & Zhanying Feng & Siyu Pan & Haojie Lu & Andre G. Uitterlinden & Tamar Nijsten & Arfan Ikram & Fernando Rivadeneira & Mohsen Ghanbari & Yong Wang & Manfred Kayser , 2022. "Combining genome-wide association studies highlight novel loci involved in human facial variation," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

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