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The fin-to-limb transition as the re-organization of a Turing pattern

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  • Koh Onimaru

    (Systems Biology Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
    Universitat Pompeu Fabra (UPF)
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology)

  • Luciano Marcon

    (Systems Biology Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
    Universitat Pompeu Fabra (UPF))

  • Marco Musy

    (Systems Biology Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
    Universitat Pompeu Fabra (UPF))

  • Mikiko Tanaka

    (Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology)

  • James Sharpe

    (Systems Biology Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
    Universitat Pompeu Fabra (UPF)
    Institució Catalana de Recerca i Estudis Avançats (ICREA))

Abstract

A Turing mechanism implemented by BMP, SOX9 and WNT has been proposed to control mouse digit patterning. However, its generality and contribution to the morphological diversity of fins and limbs has not been explored. Here we provide evidence that the skeletal patterning of the catshark Scyliorhinus canicula pectoral fin is likely driven by a deeply conserved Bmp–Sox9–Wnt Turing network. In catshark fins, the distal nodular elements arise from a periodic spot pattern of Sox9 expression, in contrast to the stripe pattern in mouse digit patterning. However, our computer model shows that the Bmp–Sox9–Wnt network with altered spatial modulation can explain the Sox9 expression in catshark fins. Finally, experimental perturbation of Bmp or Wnt signalling in catshark embryos produces skeletal alterations which match in silico predictions. Together, our results suggest that the broad morphological diversity of the distal fin and limb elements arose from the spatial re-organization of a deeply conserved Turing mechanism.

Suggested Citation

  • Koh Onimaru & Luciano Marcon & Marco Musy & Mikiko Tanaka & James Sharpe, 2016. "The fin-to-limb transition as the re-organization of a Turing pattern," Nature Communications, Nature, vol. 7(1), pages 1-9, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11582
    DOI: 10.1038/ncomms11582
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    Cited by:

    1. Zhang, Huimin & Gao, Jian & Gu, Changgui & Long, Yongshang & Shen, Chuansheng & Yang, Huijie, 2024. "Turing-like patterns induced by the competition between two stable states in a discrete-time predator–prey model," Chaos, Solitons & Fractals, Elsevier, vol. 180(C).

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